Development mechanism of life-style disease based on chronic inflammation by fetal exposure to DEHP
| Project/Area Number |
26860437
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Nagoya University |
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Principal Investigator |
Hayashi Yumi 名古屋大学, 医学(系)研究科(研究院), 助教 (30632707)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 胎生期低栄養 / 生活習慣病 / 胎生期曝露 |
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| Outline of Final Research Achievements |
DEHP exposure during fetal period upregulated food consumption after weaning, and increased blood glucose and cholesterol level in adult stage. These effects suggest that fetal exposure to DEHP may cause diabetes or dyslipidemia in adult life. On the other hand, it was unlikely that these mice exposed DEHP presented with intense inflammatory condition, therefore, we will consider new methods for evaluating mild inflammation in the future. In addition, we established new analytical method of metabolomics, and the influence on metabolomics of fetal exposure to DEHP will evaluate using this method.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Intact endogenous metabolite analysis of mice liver by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its preliminary application to in vivo real-time analysis2016
Author(s)
Kei Zaitsu*, Yumi Hayashi, Tasuku Murata, Tomomi Ohara, Kenta Nakagiri, Maiko Kusano, Hiroki Nakajima, Tamie Nakajima, Tetsuya Ishikawa, Hitoshi Tsuchihashi, Akira Ishii
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Journal Title
Analytical Chemistry
Volume: 88(7)
Issue: 7
Pages: 3556-3561
DOI
Related Report
Peer Reviewed
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