Elucidation of the underlying mechanisms by which nanomaterial lead to the development and/or exacerbation of allergic diseases

• Project/Area Number: 26860438
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Kyoto University
• Principal Investigator: Honda Akiko 京都大学, 工学(系)研究科(研究院), 助教 (20454324)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ナノマテリアル / アレルギー / 気管支喘息 / 気道上皮細胞 / 免疫担当細胞

Outline of Final Research Achievements

We investigated the effects of nanomaterial on respiratory and immune cells to elucidate the underlying mechanisms by which nanomaterial lead to the development and/or exacerbation of allergic diseases such as asthma. Nanomaterial decreased cell viability of airway epithelial cells and increased expression of cell surface molecules on antigen presenting cells in the presence of allergen. This study indicates nanomaterial can contribute to the development and/or exacerbation of asthma by disruption of respiratory and immune systems, especially by the activation of antigen presenting cells.