Effects of end-of-life discussions on the mental health of bereaved family members and quality of patient death and care

• Project/Area Number: 26860478
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kobe University
• Principal Investigator: Yamaguchi Takashi 神戸大学, 医学部附属病院, 特定助教 (10725394)
• Research Collaborator: Miyashita Mitsunori ; Morita Tatsuya
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 終末期 / アドバンスケアプランニング / がん / 遺族 / うつ / 複雑悲嘆 / 望ましい死 / 終末期に関する話し合い / Quality of death / End of life discussion / Quality of life / がん患者

Outline of Final Research Achievements

End-of-life (EOL) discussions are crucial for providing appropriate care to patients with advanced cancer at the end of their lives. To explore associations between EOL discussions and bereaved families’ depression and complicated grief, as well as the quality of patient death and EOL care, we conducted nationwide questionnaire survey of bereaved family members.80.6% of the respondents reported that they had EOL discussions.bereaved family members who had EOL discussions had a lower frequently of depression and complicated grief. EOL discussions were associated with better quality of death and EOL care.

Research Products

• [Journal Article] Predictors of response to corticosteroids for dyspnea in advanced cancer patients: a preliminary multicenter prospective observational study (2017)
  • Author(s): Mori M, Shirado AN, Morita T, Okamoto K, Matsuda Y, Matsumoto Y, Yamada H, Sakurai H, Aruga E, Kaneishi K, Watanabe H, Yamaguchi T, Odagiri T, Hiramoto S, Kohara H, Matsuo N, Katayama H, Nishi T, Matsui T, Iwase S.
  • Journal Title: Support Care Cancer Volume: 25 Issue: 4 Pages: 1169
  • DOI: 10.1007/s00520-016-3507-5
  • URL: https://pure.teikyo.jp/en/publications/e1c29db4-e929-43e9-9356-dba32c3301d5
  • Peer Reviewed
• [Journal Article] A prospective, multicenter cohort study to validate a simple performance status-based survival prediction system for oncologists. (2017)
  • Author(s): Yamada T, Morita T, Maeda I, Inoue S, Ikenaga M, Matsumoto Y, Baba M, Sekine R, Yamaguchi T, Hirohashi T, Tajima T, Tatara R, Watanabe H, Otani H, Takigawa C, Matsuda Y, Ono S, Ozawa T, Yamamoto R, Shishido H, Yamamoto N.
  • Journal Title: Cancer Volume: 123 Issue: 8 Pages: 2017-2017
  • DOI: 10.1002/cncr.30484
  • Peer Reviewed
• [Journal Article] Predictors of Responses to Corticosteroids for Cancer-Related Fatigue in Advanced Cancer Patients: A Multicenter, Prospective, Observational Study (2016)
  • Author(s): Matsuo N, Morita T, Matsuda Y, Okamoto K, Matsumoto Y, Kaneishi K, Odagiri T, Sakurai H, Katayama H, Mori I, Yamada H, Watanabe H, Yokoyama T, Yamaguchi T, Nishi T, Shirado A, Hiramoto S, Watanabe T, Kohara H, Shimoyama S, Aruga E, Baba M, Sumita K, Iwase S.
  • Journal Title: J Pain Symptom Manage. Volume: 52 Issue: 1 Pages: 64
  • DOI: 10.1016/j.jpainsymman.2016.01.015
  • Peer Reviewed
• [Journal Article] Treatment Recommendations for Respiratory Symptoms in Cancer Patients: Clinical Guidelines from the Japanese Society for Palliative Medicine. (2016)
  • Author(s): Yamaguchi T, Goya S, Kohara H, Watanabe H, Mori M, Matsuda Y, Nakamura Y, Sakashita A, Nishi T, Tanaka K.
  • Journal Title: J Palliat Med Volume: 19 Issue: 9 Pages: 925-35
  • DOI: 10.1089/jpm.2016.0145
  • Peer Reviewed
• [Journal Article] Effect of continuous deep sedation on survival in patients with advanced cancer (J-Proval): a propensity score-weighted analysis of a prospective cohort study. (2016)
  • Author(s): Maeda I, Morita T, Yamaguchi T, Inoue S, Ikenaga M, Matsumoto Y, Sekine R, Yamaguchi T, Hirohashi T, Tajima T, Tatara R, Watanabe H, Otani H, Takigawa C, Matsuda Y, Nagaoka H, Mori M, Tei Y, Kikuchi A, Baba M, Kinoshita H.
  • Journal Title: Lancet Oncol Volume: 17 Issue: 1 Pages: 115-122
  • DOI: 10.1016/s1470-2045(15)00401-5
  • Peer Reviewed
• [Journal Article] Multicenter cohort study on the survival time of cancer patients dying at home or in a hospital: Does place matter? (2016)
  • Author(s): Hamano J, Yamaguchi T, Maeda I, Suga A, Hisanaga T, Ishihara T, Iwashita T, Kaneishi K, Kawagoe S, Kuriyama T, Maeda T, Mori I, Nakajima N, Nishi T, Sakurai H, Shimoyama S, Shinjo T, Shirayama H, Yamada T, Morita T
  • Journal Title: Cancer Volume: 122 Issue: 9 Pages: 1453-1460
  • DOI: 10.1002/cncr.29844
  • Peer Reviewed
• [Journal Article] Surprise Questions for Survival Prediction in Patients With Advanced Cancer: A Multicenter Prospective Cohort Study. (2015)
  • Author(s): Hamano J, Morita T, Inoue S, Ikenaga M, Matsumoto Y, Sekine R, Yamaguchi T, Hirohashi T, Tajima T, Tatara R, Watanabe H, Otani H, Takigawa C, Matsuda Y, Nagaoka H, Mori M, Yamamoto N, Shimizu M, Sasara T, Kinoshita H.
  • Journal Title: Oncologist Volume: 20 Issue: 7 Pages: 839-844
  • DOI: 10.1634/theoncologist.2015-0015
  • Peer Reviewed
• [Journal Article] Survival prediction for advanced cancer patients in the real world: A comparison of the Palliative Prognostic Score, Delirium-Palliative Prognostic Score, Palliative Prognostic Index and modified Prognosis in Palliative Care Study predictor model. (2015)
  • Author(s): Baba M, Maeda I, Morita T, Inoue S, Ikenaga M, Matsumoto Y, Sekine R, Yamaguchi T, Hirohashi T, Tajima T, Tatara R, Watanabe H, Otani H, Takigawa C, Matsuda Y, Nagaoka H, Mori M, Tei Y, Hiramoto S, Suga A, Kinoshita H.
  • Journal Title: Eur J Cancer Volume: 51 Issue: 12 Pages: 1618-1629
  • DOI: 10.1016/j.ejca.2015.04.025
  • Peer Reviewed
• [Journal Article] これからのことを話し合う：アドバンス・ケア・プランニング (2015)
  • Author(s): 木澤義之、山口崇、余谷暢之
  • Journal Title: ペインクリニック Volume: 36
• [Presentation] End-of-life discussions with advanced cancer patients and their effects on bereaved families’ mental health. (2016)
  • Author(s): Yamaguchi T.
  • Organizer: Palliative Care in Oncology Symposium 2016
  • Place of Presentation: San Fransisco, CA, USA
  • Year and Date: 2016-09-09
  • Int'l Joint Research