Investigation of the mechanism underlying the effect of fatty acid on colorectal carcinogenesis

• Project/Area Number: 26860517
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: ENDO HIROKI 横浜市立大学, 附属病院, 助教 (70468164)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大腸発癌 / 脂肪酸 / 大腸発がん

Outline of Final Research Achievements

We established the method how to evaluate the effect of saturated fatty acid on colorectal carcinogenesis by continuous jugular infusion or intraperitoneal injection of fatty acid. We clarified that saturated fatty acid (palmitate) acts as a growth factor for colonic epithelial cell proliferation in colon carcinogenesis via saturated fatty acid/Toll-like receptor 4/JNK pathway.

Research Products

• [Journal Article] Association between factors associated with colorectal cancer and rectal aberrant crypt foci in humans. (2015)
  • Author(s): Akiko Ezuka, Eiji Sakai, Kenichi Kawana, Hajime Nagase, Yukio Kakuta, Shiori Uchiyama, Hidenori Ohkubo, Takuma Higurashi, Takashi Nonaka, Hiroki Endo, Hirokazu Takahashi, Atsushi Nakajima.
  • Journal Title: Oncol Lett. Volume: １０ Issue: 6 Pages: 3689-95
  • DOI: 10.3892/ol.2015.3763
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visual distraction alone for the improvement of colonoscopy-related pain and satisfaction. (2015)
  • Author(s): Shotaro Umezawa, Takuma Higurashi, Shiori Uchiyama, Eiji Sakai, Hidenori Ohkubo, Hiroki Endo, Takashi Nonaka, Atsushi Nakajima.
  • Journal Title: World J Gastroenterol. Volume: 21 Issue: 15 Pages: 4707-14
  • DOI: 10.3748/wjg.v21.i15.4707
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 肥満・生活習慣病と大腸癌 (2014)
  • Author(s): 遠藤宏樹、日暮琢磨、高橋宏和、中島 淳
  • Journal Title: 日本消化器内視鏡学会雑誌 Volume: 55 Pages: 3735-3744
  • NAID: 130003386602
• [Journal Article] 肥満関連疾患をターゲットとしたメトホルミンによる大腸腫瘍の科学予防の可能性 (2014)
  • Author(s): 23.日暮琢磨、酒井英嗣、内山詩織、梅沢翔太郎、遠藤宏樹、高橋宏和、中島淳
  • Journal Title: 消化器内科 Volume: 58 Pages: 612-616
• [Journal Article] Methylation epigenotypes and genetic features in colorectal laterally spreading tumors (2014)
  • Author(s): Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A.
  • Journal Title: Int J Cancer Volume: in press Issue: 7 Pages: 1586-95
  • DOI: 10.1002/ijc.28814
  • Peer Reviewed / Open Access
• [Presentation] Metformin efficacy and safety for colorectal polyps: A double-blind randomized controlles trial. (2015)
  • Author(s): Takuma Higurashi, Kunihiro Hosono, Shotaro Umezawa, Shiori Uchiyama, Takashi Uchiyama, Hiroki Endo, Atsushi Nakajima.
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] 大腸上皮における飽和脂肪酸の影響． (2015)
  • Author(s): 内山詩織、日暮琢磨、梅沢翔太郎、遠藤宏樹、中島淳
  • Organizer: 第23回日本消化器関連学会週間（JDDW 2015）
  • Place of Presentation: グランドプリンスホテル高輪（東京都港区）
  • Year and Date: 2015-10-08
• [Presentation] 当院における大腸カプセル内視鏡施行例の検討． (2015)
  • Author(s): 梅沢 翔太郎、遠藤 宏樹、鹿野島 健二、稲生 優海、松浦 瑞恵、冬木 晶子、内山 詩織、酒井 英嗣、大久保 秀則、日暮 琢磨、飯田 洋、野中 敬、中島 淳
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-04-23
• [Presentation] EICOSAPENTAENOIC ACID (EPA) SUP-PRESSES COLORECTAL ABERRANT CRYPT FOCI (ACF) AND CELL PROLIFERATION IN COLORECTAL EPITHELIUM VIA GPR120 (2014)
  • Author(s): 84Higurashi T , Uchiyama S , Umezawa S , Sakai E , Ohkubo H , Endo H , Takahashi H , Nakajima A
  • Organizer: 22nd United European Gastroenterology Week
  • Place of Presentation: Vienna（オーストリア）
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] GPR120 経路をターゲットとしたエイコサペントエン酸（EPA）による大腸腫瘍化学予防 (2014)
  • Author(s): 72梅沢翔太郎, 日暮琢磨, 内山詩織, 酒井英嗣, 遠藤宏樹, 中島淳
  • Organizer: 第131回日本薬理学会関東部会
  • Place of Presentation: 横浜市立大学（神奈川県）
  • Year and Date: 2014-10-11
• [Presentation] AMPK-mTOR 経路をターゲットとしたメトホルミンによる大腸腫瘍化学予防 (2014)
  • Author(s): 73日暮琢磨, 梅沢翔太郎, 内山詩織, 酒井英嗣, 細野邦弘, 遠藤宏樹, 中島淳
  • Organizer: 第131回日本薬理学会関東部会
  • Place of Presentation: 横浜市立大学（神奈川県）
  • Year and Date: 2014-10-11
• [Remarks] 横浜市立大学附属病院消化器内科 肝胆膵消化器病学教室
  • URL: http://ycuhepabiligi.wix.com/home