Increased TNF-R1 expression as a promising biomarker of human colorectal cancer

Research Project

Project/Area Number	26860519
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Yokohama City University
Principal Investigator	HOSONO Kunihiro 横浜市立大学, 附属病院, 助教 (50537339)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	大腸癌 / バイオマーカー / TNF-α / TNF-R1
Outline of Final Research Achievements	The proinflammatory cytokine, tumor necrosis factor (TNF)-α, is a major mediator of cancer-related inflammation. However, little has been reported on the relation between TNF-α and sporadically occurring colorectal neoplasms. The aim of this study was to determine the expression statuses of TNF-α and its receptors in colorectal cancer. We measured the serum concentrations of TNF-α and those of its receptors in colorectal cancer patients and healthy controls. The serum levels of sTNF-R1 in cancer patients were significantly higher as compared with those in the control group. ROC analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) in patients for the diagnosis of colorectal cancer. These results suggest that TNF-R1 may only be a promising biomarker of colorectal cancer, but also play an important role in the very early stage of colorectal carcinogenesis.