Increased TNF-R1 expression as a promising biomarker of human colorectal cancer
| Project/Area Number |
26860519
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大腸癌 / バイオマーカー / TNF-α / TNF-R1 |
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| Outline of Final Research Achievements |
The proinflammatory cytokine, tumor necrosis factor (TNF)-α, is a major mediator of cancer-related inflammation. However, little has been reported on the relation between TNF-α and sporadically occurring colorectal neoplasms. The aim of this study was to determine the expression statuses of TNF-α and its receptors in colorectal cancer. We measured the serum concentrations of TNF-α and those of its receptors in colorectal cancer patients and healthy controls. The serum levels of sTNF-R1 in cancer patients were significantly higher as compared with those in the control group. ROC analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) in patients for the diagnosis of colorectal cancer. These results suggest that TNF-R1 may only be a promising biomarker of colorectal cancer, but also play an important role in the very early stage of colorectal carcinogenesis.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.2016
Author(s)
Higurashi T, Hosono K, Takahashi H, Komiya Y, Umezawa S, Sakai E, Uchiyama T, Taniguchi L, Hata Y, Uchiyama S, Hattori A, Nagase H, Kessoku T, Arimoto J, Matsuhashi N, Inayama Y, Yamanaka S, Taguri M, Nakajima A.
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Journal Title
Lancet Oncol.
Volume: 17
Issue: 4
Pages: 475-783
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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