New therapy for pulmonary hypertension using prostaglandin I2 incorporated nanoparticles
| Project/Area Number |
26860563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Okayama University |
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Principal Investigator |
AKAGI Satoshi 岡山大学, 医歯(薬)学総合研究科, 助教 (60601127)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ベラプロスト封入ナノ粒子 / sugen/hypoxiaラット / モノクロタリンラット / 気管内投与 / 肺高血圧 / 肺高血圧症 / ナノテクノロジー |
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| Outline of Final Research Achievements |
We prepare the beraprost incorporated nanoparticles (BPS-NPs) and investigated the effects on pulmonary hypertension in Sugen-hypoxia and monocrotaline rat models of pulmonary arterial hypertension (PAH). We examined the right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH) and pulmonary vascular remodeling 2 weeks after the intratracheal administration of PBS, FITC incorporated nanoparticle (FITC-NPs) and BPS-NPs. BPS-NPs significantly decreased RVSP, RVH and pulmonary vascular remodeling compared with PBS and FITC-NPs in Sugen-hypoxia and monocrotaline rat models. Furthermore, BPS-NPs significantly improved survival rate compared with PBS and FITC-NPs in monocrotaline rat models.
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Report
(3 results)
Research Products
(4 results)
