New therapy for pulmonary hypertension using prostaglandin I2 incorporated nanoparticles

• Project/Area Number: 26860563
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Okayama University
• Principal Investigator: AKAGI Satoshi 岡山大学, 医歯(薬)学総合研究科, 助教 (60601127)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ベラプロスト封入ナノ粒子 / sugen/hypoxiaラット / モノクロタリンラット / 気管内投与 / 肺高血圧 / 肺高血圧症 / ナノテクノロジー

Outline of Final Research Achievements

We prepare the beraprost incorporated nanoparticles (BPS-NPs) and investigated the effects on pulmonary hypertension in Sugen-hypoxia and monocrotaline rat models of pulmonary arterial hypertension (PAH). We examined the right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH) and pulmonary vascular remodeling 2 weeks after the intratracheal administration of PBS, FITC incorporated nanoparticle (FITC-NPs) and BPS-NPs. BPS-NPs significantly decreased RVSP, RVH and pulmonary vascular remodeling compared with PBS and FITC-NPs in Sugen-hypoxia and monocrotaline rat models. Furthermore, BPS-NPs significantly improved survival rate compared with PBS and FITC-NPs in monocrotaline rat models.

Research Products

• [Presentation] Intratracheal administration of prostacyclin analog-incorporated nanoparticles ameliorates the development of monocrotaline and sugen/hypoxia-induced pulmonary arterial hypertension (2016)
  • Author(s): 赤木 達
  • Organizer: 第80回日本循環器学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-17
• [Presentation] プロスタサイクリン誘導体封入ナノ粒子を用いた新規肺高血圧治療法の開発 (2014)
  • Author(s): 赤木 達、中村一文、松原広己、伊藤 浩
  • Organizer: 第105回日本循環器学会中国地方会
  • Place of Presentation: 宇部
  • Year and Date: 2014-12-06
• [Presentation] PGI2封入ナノ粒子を用いた肺高血圧症の新規治療法 (2014)
  • Author(s): 赤木 達、中村一文、更科俊洋、江頭健輔、伊藤 浩
  • Organizer: 第2回日本肺高血圧学会/第3回日本肺循環学会合同学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03 – 2014-10-05
• [Presentation] Intratracheal administration of prostacyclin analog-incorporated nanoparticles ameliorates the development of monocrotaline-induced pulmonary artery hypertension in rats (2014)
  • Author(s): S Akagi, K Nakamura, H Matsubara, H Ito
  • Organizer: ESC CONGRESS 2014
  • Place of Presentation: BARCELONA
  • Year and Date: 2014-08-30 – 2014-09-03