The role of basophils in bleomycin induced lung fibrosis

• Project/Area Number: 26860601
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TATEISHI Tomoya 東京医科歯科大学, 医学部附属病院, 助教 (40645636)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 間質性肺炎 / 好塩基球 / 肺線維症 / HMGB1 / 動物実験 / マウス好塩基球

Outline of Final Research Achievements

Depletion of basophils augmented lung fibrosis induced by bleomycin in histological analysis. Microarray analysis revealed that Hmgb1 gene expression is significantly augmented in basophil-depleted mice. Besides, Hmgb1 gene expression is also augmented in IL4-depleted mice and IL4 receptor knock out mice. These findings support the hypothesis that basophils have anti-fibrotic role through suppressing HMGB1 production.