| Project/Area Number |
26860641
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生理的小胞体ストレス応答 / 腎臓 / 小胞体ストレス / 腎疾患 |
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| Outline of Final Research Achievements |
The unfolded protein response (UPR) implicates in renal diseases. However, recent studies indicated that physiological UPR, which is known as weak signaling pathway, associated to various biological phenomena. Here, this study investigated that activation mechanisms of physiological UPR in kidney and especially focused on regulator and adaptor proteins of ER stress sensors. I found that (1) a novel regulator proteins were identified, (2) down-regulation of regulator proteins was alleviated stress-induced renal injury and apoptosis in both in vitro and in vivo, (3) identified regulator proteins interacted with ER stress sensors, which was substantially enhanced during stress condition. These data suggest a possibility that the proper activation of physiological UPR contribute to cell homeostasis in kidney.
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