• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of Sirtuin on diabetic nephropatfunctionhy based on maintaining mitochondrial

Research Project

Project/Area Number 26860651
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionKanazawa Medical University

Principal Investigator

WATANABE Ai  金沢医科大学, 医学部, 助教 (70625722)

Research Collaborator KITADA Munehiro  金沢医科大学, 医学部, 准教授 (40434469)
KOYA Daisuke  金沢医科大学, 医学部, 教授 (70242980)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords糖尿病腎症 / Sirt3 / ミトコンドリア / 酸化ストレス / CD38 / オートファジー / カロリー制限 / サーチュイン / ミトコンドリア
Outline of Final Research Achievements

Mitochondrial (Mt) oxidative stress, which is important for the pathogenesis of diabetic nephropathy, is caused by the breakdown of active oxygen species production / antioxidant balance and Mt function decline / homeostatic maintenance. The NAD + dependent deacetylase (Sirt 3) plays an important role in controlling Mt redox and Mt homeostasis. In renal proximal tubular cells of Zucker Diabetic fatty rats, the increase in NAD + consumption posibly due to the increased expression of CD38, which is known as NAD+ degrading enzyme, and the decrease in Sirt 3 function contributed to the enhancement of Mt oxidative stress。And than, the autophagy function is impaired in the kidney of diabetic rats, resulting in the accumulation of abnormal Mt and the breakdown of Mt homeostasis, which is involved in the initiation and progression of diabetic nephropathy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] Sirt3機能低下は糖尿病腎近位尿細管におけるミトコンドリア酸化ストレスの増2017

    • Author(s)
      小倉慶雄、北田宗弘、鈴木妙子、門野至、渡邊愛、古家大祐
    • Organizer
      第60回日本糖尿病学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2017-05-18
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi