Research Project
Grant-in-Aid for Young Scientists (B)
To investigate the hypothesis that Rfx6 and Rfx3 cooperate with each other and are involved in the regulation of GIP expression in K-cell, we evaluated the effect of knockdown and overexpression of Rfx6 and Rfx3 on GIP gene expression using STC-1 cell line. GIP mRNA expression levels were significantly decreased in Rfx6- knockdown STC-1 cells as we have previously reported. However, Rfx3 knockdown had no effect on GIP gene expression. In addition, simultaneous knockdown of Rfx6 and Rfx3 in STC-1 cells resulted in no change in GIP gene expression compared to single knockdown of Rfx6. Increased GIP expression levels were observed in Rfx6-overexpressiing STC-1 cells and GIP expression levels in Rfx6/Rfx3- overexpressing cells were similar to those in Rfx6-overexpressiing STC-1 cells.
All 2016 2015 2014
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results)
J Diabetes Investig.
Volume: 7 Issue: 2 Pages: 166-8
10.1111/jdi.12390
120005770741
Volume: 6 Issue: 3 Pages: 302-308
10.1111/jdi.12289
Am J Physiol Endocrinol Metab
Volume: 308 Issue: 7 Pages: 583-591
10.1152/ajpendo.00543.2014
Endocrinology
Volume: 156 Issue: 3 Pages: 837-837
10.1210/en.2014-1653