The mechanism of erythroid lineage caused by Myh9 R702C mutation
Project/Area Number |
26860725
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Nagoya University |
Principal Investigator |
Suzuki Nobuaki 名古屋大学, 医学部附属病院, 助教 (70637686)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | MYH9 / 赤血球 / 赤血球文化 / MYH9異常症 / マウスモデル / 造血機能 |
Outline of Final Research Achievements |
We generated hematopoietic stem cell(HSC)-specific Myh9 R702C mice, and estimated red blood cells (RBCs) and cells of the erythroid lineage. HSC-specific Myh9 R702C mice displayed mild anemia and high erythropoietin level compared with wild type mice. However, we could not find no difference in the character of RBC and differentiation of erythroid lineage compared with wild type mice in this research.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Endoscopic treatment of esophageal varices in hemophiliac patients with liver cirrhosis2015
Author(s)
Ishizu Y, Ishigami M, Suzuki N, Kuzuya T, Honda T, Hayashi K, Katano Y, Hirooka Y, Ishikawa T, Matsushita T, Goto H.
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Journal Title
Gastrointest Endosc
Volume: 81
Issue: 4
Pages: 1059-1060
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Rhof promotes murine marginal zone B cell development2014
Author(s)
Kishimoto M, Matsuda T, Yanase S, Katsumi A, Suzuki N, Ikejiri M, Takagi A, Ikawa M, Kojima T, Kunishima S, Kiyoi H, Naoe T, Matsushita T, Maruyama M.
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Journal Title
Nagoya J Med Sci
Volume: 76
Pages: 293-305
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] A case of MYH9 disorders caused by a novel mutation (P.K74E)2015
Author(s)
Takeshi Kanematsu, Nobuaki Suzuki, Mayuko Kishimoto, Tomohiro Aoki, Mika Ogawa, Yoshitoyo Kagami, Shinji Kunishima, Hitoshi Kiyoi, Tadashi Matsushita
Organizer
International Society Thrombosis and Hemostasis 2015 Congress
Place of Presentation
トロント (カナダ)
Year and Date
2015-06-20
Related Report
Int'l Joint Research
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[Presentation] 新規変異を有するMYH9異常症の1例2015
Author(s)
兼松 毅, 鈴木 伸明, 小川 実加, 岸本 磨由子, 國島 伸治, 松下 正
Organizer
第37回日本血栓止血学会学術集会
Place of Presentation
甲府市総合市民会館 (山梨県甲府市)
Year and Date
2015-05-21
Related Report
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[Presentation] α-Storage Pool病の1例2014
Author(s)
兼松 毅, 岸本 磨由子, 鈴木 伸明, 國島 伸治, 松下 正
Organizer
日本血栓止血学会
Place of Presentation
大阪国際交流センター 大阪府大阪市
Year and Date
2014-05-29 – 2014-05-31
Related Report
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[Presentation] 遺伝子改変マウスを用いたsamll GTPase RhoFの機能解析2014
Author(s)
岸本 磨由子, 松田 剛典, 簗瀬 正吾, 鈴木 伸明, 池尻 誠, 高木 明, 國島 伸治, 小嶋 哲人, 直江 知樹, 丸山 光生, 勝見 章, 松下 正
Organizer
日本血栓止血学会
Place of Presentation
大阪国際交流センター 大阪府大阪市
Year and Date
2014-05-29 – 2014-05-31
Related Report
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