| Project/Area Number |
26860729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
|
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| Research Institution | Shiga University of Medical Science (2015)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 造血分化 / ヒストンメチル化 / 白血病 / 造血幹細胞 / ヒストン脱メチル化酵素 / 血球分化 / DNA損傷ストレス |
|---|
| Outline of Final Research Achievements |
In the current study, we focused the hematological function of a histone lysine demethylase, KDM4B, that is reported to be associated with DNA-damage stress and hypoxia stress and is overexpressed in primary acute myeloid leukemia cells. Knockdown or overexpression of KDM4B did not enhance the proliferation capacity nor affect response against DNA-damage stress in leukemmia cells. However, overexpression of KDM4B in hematopoietic stem cells promoted the differentiation towards granulocytes. These data suggest that KDM4B could be involved with myeloid differentiation.
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