| Project/Area Number |
26860746
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Saito Tetsuya 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10360926)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関節リウマチ / 滑膜線維芽細胞 / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
In rheumatoid arthritis, synovial fibroblasts produce a variety of inflammatory cytokines and tissue-degrading enzymes, leading to cartilage and bone destruction. The origin of pathogenic synovial fibroblasts has not yet been elucidated, although bone marrow-derived cells and normal synovial fibroblasts are suspected to be a candidate. In this study, we revealed that resident mesenchymal cells in the synovial tissues are a progenitor of pathogenic synovial fibroblasts, indicating that synovial resident mesenchymal stem cells are a candidate of progenitors.
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