| Project/Area Number |
26860776
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | Tokyo Metropolitan Institute of Medical Science |
|---|
Principal Investigator |
IKEJIRI Ai 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (30528295)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | Influenza / HIF-1a / Dendritic cells / インフルエンザ / 樹状細胞 / 急性呼吸窮迫症候群 / HIF-1α / インフルエンザウイルス / IL-6 |
|---|
| Outline of Final Research Achievements |
H5N1 high pathogenic avian influenza causes elevated mortality and acute respiratory distress syndrome (ARDS). I focused on the antigen presenting cell, dendritic cells, which have an important roll of the production of antibody against virus. In H5N1 infection, the number of dendritic cells interacted with T cells was decreased and impaired the production of antibody. Furthermore, H5N1 vaccine based on Vaccinia virus protected effectively against H5N1 infection due to the increase of the number of dendritic cells interacted with T cells and the induction of antibody. I identified the mechanism of associated with the severe symptoms seen with H5N1 infection.
|
