| Project/Area Number |
26860787
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | University of Fukui |
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Principal Investigator |
Hayashi Hisako 福井大学, 学術研究院医学系部門, 特別研究員 (70584853)
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| Research Collaborator |
Yamada Kenta 福井大学, 学術研究院医学系部門(附属病院部), 医員
Ohshima Yusei 福井大学, 学術研究院医学系部門, 教授
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 気道リモデリング / 線維細胞 / IFN-beta / IFN-lamda / 繊維細胞 / IL-9 / IFN-Lamda / 気道感染 |
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| Outline of Final Research Achievements |
Airway remodeling is associated with the severity of bronchial asthma. We focused on fibrocytes, a precursor cell of myofibroblasts, which play an important role in airway remodeling and analyzed the effects of respiratory viral infection, an exacerbation factor of asthma on the function of fibrocytes. Fibrocytes were stimulated with IFN-beta, which is produced in innate immune response to virus. IFN-beta suppressed cell proliferation, differentiation into myofibroblasts, and YKL-40 production by fibrocytes. Inhalation of IFN-beta has been evaluated as a therapeutic measure of bronchial asthma. Our data suggested the possibility that inhalation of IFN-beta might be useful for prevention of the development of airway remodeling by suppressing fibrocyte function.
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