| Project/Area Number |
26860795
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto University |
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Principal Investigator |
SAIDA SATOSHI 京都大学, 医学(系)研究科(研究院), 助教 (70638254)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Etsuro 弘前大学, 小児科, 教授 (20168339)
NAKAHATA Tatsutoshi 京都大学, iPS細胞研究所, 教授 (20110744)
OGAWA Seishi 京都大学, 大学医医学研究科, 教授 (60292900)
WATANABE Ken-ichiro 京都大学, 大学院医学研究科, 臨床教授 (20324634)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 白血病 / ダウン症候群 / 一過性異常骨髄増殖症 / 急性巨核芽球性白血病 / TAM / AMKL / NOGマウス / 異種移植 |
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| Outline of Final Research Achievements |
Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder in neonates of Down syndrome. In this study, we established a xenograft model of the leukemia, which mimicked the progression of TAM to myeloid leukemia (ML-DS). Using comprehensive genetic and epigenetic analyses in this xenograft model, we found an important factor in a progression from TAM to ML-DS.
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