Reference value development of the glomerular filtration rate of the low birth weight infants using the plasma inulin clearance

• Project/Area Number: 26860825
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Juntendo University
• Principal Investigator: NISHIZAKI Naoto 順天堂大学, 医学部, 助教 (30561435)
• Research Collaborator: MURANO Yayoi 順天堂大学, 医学部, 非常勤助教 (80771922) ; NAKAGAWA Mayu 順天堂大学, 医学部, 非常勤助教 ; HIRANO Daishi 東京慈恵会医科大学, 医学部, 助教 (90424663)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 早産児 / 低出生体重児 / ネフロン / 慢性腎障害 / 未熟網膜症 / 酸素毒性 / DOHaD / ネフロン数 / 腎障害 / DOHaD理論 / 尿アンギオテンシノーゲン / 尿中アンギオテンシノーゲン / FGRラット / 酸化ストレス

Outline of Final Research Achievements

In this study, we examined chronic renal impairment after the growth of the premature infants. First, urinary angiotensinogen (AGT) elevation prior to urinary protein levels is an useful biomarker to detect kidney impairment related prematurity. Second, renal impairment was caused by exposure to a hyperoxic environment during nephrogenesis, and the pathology of the impaired nephrogenesis in this oxygen-induced retinopathy animal model reflects the characteristics of retinopathy of prematurity observed in preterm infants.
From these findings, the clinicians should observe renal function after the growth of the premature infants carefully.

Research Products

• [Journal Article] Impaired nephrogenesis in neonatal rats with oxygen-induced retinopathy. (2017)
  • Author(s): Nakagawa M, Nishizaki N, Endo A, Someya T, Saito Y, Mizutani A, Hara T, Murano Y, Sakuraya K, Hara S, Umino D, Hirano D, Fujinaga S, Ohtomo Y, Shimizu T.
  • Journal Title: Pediatrics International Volume: Feb 16 Issue: 6 Pages: 704-710
  • DOI: 10.1111/ped.13264
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats. (2015)
  • Author(s): Murano Y, Nishizaki N, Endo A, Ikeda N, Someya T, Nakagawa M, Hara T, Sakuraya K, Hara S, Hirano D, Suzuki M, Shoji H, Fujinaga S, Ohtomo Y, Shimizu T.
  • Journal Title: Pediatr Res. Volume: 78 Issue: 6 Pages: 678-682
  • DOI: 10.1038/pr.2015.153
  • Peer Reviewed
• [Presentation] 高濃度酸素負荷新生仔ラットにおける網膜症と腎障害の関連 (2016)
  • Author(s): 仲川 真由, 西崎 直人, 遠藤 周, 染谷 朋之介, 水谷 亮, 原 太一, 村野 弥生, 平野 大志, 齋藤 雄太, 藤永 周一郎, 大友 義之, 清水 俊明
  • Organizer: 第51回日本小児腎臓病学会学術集会
  • Place of Presentation: ウインクあいち
  • Year and Date: 2016-07-07
• [Presentation] 低出生体重児とCKD (2015)
  • Author(s): 西崎直人
  • Organizer: 第15回新生児栄養フォ-ラム
  • Place of Presentation: 東京
  • Year and Date: 2015-05-30 – 2015-05-31
  • Invited
• [Presentation] 【特別講演】低出生体重児と慢性腎臓病（CKD) (2015)
  • Author(s): 西崎直人，清水俊明
  • Organizer: 第15回新生児栄養フォーラム
  • Place of Presentation: 飯田橋レインボービル（東京都千代田区）
  • Year and Date: 2015-05-30
  • Invited
• [Presentation] 【分野別シンポジウム】新生児における尿中アンジオテンシノーゲンの意義 (2015)
  • Author(s): 西﨑直人，村野弥生，大日方薫，清水俊明
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-19
  • Invited
• [Presentation] 新生児における尿中アンジオテンシノーゲンの意義 (2015)
  • Author(s): 西崎直人
  • Organizer: 第118回日本小児科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-17 – 2015-04-19
  • Invited
• [Book] Neonatal Care (2015)
  • Author(s): 西崎直人，清水俊明
  • Publisher: メディカ出版