| Project/Area Number |
26860825
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
MURANO Yayoi 順天堂大学, 医学部, 非常勤助教 (80771922)
NAKAGAWA Mayu 順天堂大学, 医学部, 非常勤助教
HIRANO Daishi 東京慈恵会医科大学, 医学部, 助教 (90424663)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 早産児 / 低出生体重児 / ネフロン / 慢性腎障害 / 未熟網膜症 / 酸素毒性 / DOHaD / ネフロン数 / 腎障害 / DOHaD理論 / 尿アンギオテンシノーゲン / 尿中アンギオテンシノーゲン / FGRラット / 酸化ストレス |
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| Outline of Final Research Achievements |
In this study, we examined chronic renal impairment after the growth of the premature infants. First, urinary angiotensinogen (AGT) elevation prior to urinary protein levels is an useful biomarker to detect kidney impairment related prematurity. Second, renal impairment was caused by exposure to a hyperoxic environment during nephrogenesis, and the pathology of the impaired nephrogenesis in this oxygen-induced retinopathy animal model reflects the characteristics of retinopathy of prematurity observed in preterm infants.
From these findings, the clinicians should observe renal function after the growth of the premature infants carefully.
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