The role of microRNAs in the pathogenesis of dermatofibrosarcoma protuberans.
Project/Area Number |
26860886
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Kumamoto University |
Principal Investigator |
Kajihara Ikko 熊本大学, 大学院生命科学研究部, 特任助教 (90433036)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 隆起性皮膚線維肉腫 / miR-205 / LRP-1 |
Outline of Final Research Achievements |
In this study, we investigated the role of microRNAs in the pathogenesis of dermatofibrosacoma protuberans (DFSP). MicroRNA PCR array showed the expression of miR-205 was down-regulated in DFSP compared with dermatofibroma and normal skin. miR-205 inhibitor increased cell proliferation and low-density lipoprotein receptorrelated protein-1 (LRP-1) protein in cultured normal dermal fibroblasts. Knockdown of LRP-1 suppressed cell growth and down-regulated extracellular signal-regulated kinase (ERK) phosphorylation in cultured DFSP cells. Taken together, LRP-1 overexpression caused by the miR-205 down-regulation may play a role in the abnormal proliferation of DFSP cells via directly regulating ERK phosphorylation.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Serum concentrations of Flt-3 ligand in rheumatic diseases2015
Author(s)
Nakamura K, Nakatsuka N, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Inoue K, Fukushima S, Ihn H.
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Journal Title
BioScience Trends
Volume: 9
Issue: 5
Pages: 342-349
DOI
NAID
ISSN
1881-7815, 1881-7823
Related Report
Peer Reviewed / Open Access
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[Journal Article] NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma.2015
Author(s)
Shimozono N, Jinnin M, Masuzawa M, Masuzawa M, Wang Z, Hirano A, Tomizawa Y, Etoh-Kira T, Kajihara I, Harada M, Fukushima S, Ihn H.
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Journal Title
Cancer Res.
Volume: 75
Issue: 21
Pages: 4458-4465
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma.2015
Author(s)
Ichigozaki Y, Fukushima S, Jinnin M, Miyashita A, Nakahara S, Tokuzumi A, Yamashita J, Kajihara I, Aoi J, Masuguchi S, Zhongzhi W, Ihn H.
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Journal Title
Exp Dermatol.
Volume: 25
Issue: 1
Pages: 67-69
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.2015
Author(s)
Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H.
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Journal Title
J Immunol.
Volume: 195
Issue: 8
Pages: 3565-3573
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin.2015
Author(s)
Wang Z, Jinnin M, Kobayashi Y, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Makino T, Fukushima S, Inagaki Y, Ihn H.
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Journal Title
J Dermatol Sci.
Volume: 79
Issue: 3
Pages: 268-278
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased CCL22 expression in psoriatic skin predicts a good response to infliximab therapy.2014
Author(s)
Kusumoto S, Kajihara I, Nagamoto E, Makino K, Ichihara A, Aoi J, Johno T, Makino T, Fukushima S, Jinnin M, Ihn H.
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Journal Title
Br J Dermatol.
Volume: 171
Issue: 5
Pages: 1259-61
DOI
Related Report
Peer Reviewed
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