Longitudinal Study for Brain Functions of Remission and Recovery in Mood disorders and Schizophrenia

• Project/Area Number: 26860914
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: Takizawa Ryu 東京大学, 医学部附属病院, 助教 (30420243)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 統合失調症 / 気分障害 / 寛解 / 回復 / 脳機能 / 縦断的研究 / 双生児法 / ストレス / NIRS / fMRI / リカバリー / 縦断的研究法

Outline of Final Research Achievements

The main purpose of this research is to elucidate the underlying brain functions not only for ‘(symptomatic) Remission’ but also for ‘Recovery’ which includes social functioning, subjective well-being and quality of life (QOL). We showed the potential applicability of near-infrared spectroscopy (NIRS) for differential diagnosis of the patients with depressive symptoms. However, the applicability of NIRS to the assessment of symptom and prognostic prediction remains to be elucidated.
Prospectively we have measured the baseline, 1.5-year and 3-year follow-ups in healthy controls and patients. Our results showed that there is a possibility that prefrontal and temporal NIRS signals have state-dependent and trait-dependent characteristics (for symptoms, functioning and QOL) on the basis of differential brain regions. The current research has shown the potential applicability to the assessment of symptom and the establishment of prognostic prediction.

Research Products

• [Journal Article] Association between impaired brain activity and volume at the sub-region of Broca's area in ultra-high risk and first-episode schizophrenia: a multi-modal neuroimaging study. (2016)
  • Author(s): Norichika Iwashiro, Shinsuke Koike, Yoshihiro Satomura, Motomu Suga, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Wataru Gonoi, Ryu Takizawa, Akira Kunimatsu, Hidenori Yamasue, Kiyoto Kasai
  • Journal Title: Schizophrenia Research Volume: Epub ahead of print Issue: 1-3 Pages: 9-15
  • DOI: 10.1016/j.schres.2016.02.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between rostral prefrontal cortical activity and functional outcome in first-episode psychosis: a longitudinal functional near-infrared spectroscopy study. (2016)
  • Author(s): Koike S, Satomura Y, Kawasaki S, Nishimura Y, Takano Y, Iwashiro N, Kinoshita A, Nagai T, Natsubori T, Tada M, Ichikawa E, Takizawa R, Kasai K
  • Journal Title: Schizophr Res Volume: 170 Issue: 2-3 Pages: 304-310
  • DOI: 10.1016/j.schres.2016.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial. (2016)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y.
  • Journal Title: Neuropsychopharmacology. Volume: ４０ Issue: 12 Pages: 2676-2685
  • DOI: 10.1038/npp.2015.128
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: an imaging genetics study using multi-channel near-infrared spectroscopy. (2015)
  • Author(s): Kinoshita A, Takizawa R, Koike S, Satomura Y, Kawasaki S, Kawakubo Y, Marumo K, Tochigi M, Sasaki T, Nishimura Y, Kasai K
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 62 Pages: 13-21
  • DOI: 10.1016/j.pnpbp.2015.04.006
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Bulllying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study. (2015)
  • Author(s): Ryu Takizawa, Andrea Danese, Barbara Maughan, Louise Arseneault.
  • Journal Title: Psychol Med. Volume: 45(13) Issue: 13 Pages: 2705-2715
  • DOI: 10.1017/s0033291715000653
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: A multi-channel near-infrared spectroscopy study (2015)
  • Author(s): Okada N, Takahashi K, Nishimura Y, Koike S, Ishii-Takahashi A, Sakakibara E, Satomura Y, Kinoshita A, Takizawa R, Kawasaki S, Nakakita M, Ohtani T, Okazaki Y, Kasai K
  • Journal Title: Addict Biol Volume: 21 Issue: 2 Pages: 489-503
  • DOI: 10.1111/adb.12224
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder; a randomized controlled trial. (2015)
  • Author(s): Ayaka Ishii-Takahashi, Ryu Takizawa et al.
  • Journal Title: Neuropsychopharmacology Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A concurrent fNIRS-fMRI measurement for validation of a separation method between deep and shallow fNIRS signals with multi-distance optodes. (2015)
  • Author(s): Tsukasa Funane, Hiroki Sato, Noriaki Yahata, Ryu Takizawa, et al.
  • Journal Title: Neurophotonics Volume: 2(1) Issue: 1 Pages: 015003-015003
  • DOI: 10.1117/1.nph.2.1.015003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bulllying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study. (2015)
  • Author(s): Ryu Takizawa, Andrea Danese, Barbara Maughan, Louise Arseneault
  • Journal Title: Psychological Medicine Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Using social epidemiology and neuroscience to explore the relationship between job stress and frontotemporal cortex activity among workers. (2015)
  • Author(s): Kawasaki S, Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Yoshikawa A, Inai A, Nishioka M, Eriguchi Y, Kakiuchi C, Araki T, Kan C, Umeda M, Shimazu A, Hashimoto H, Kawakami N, Kasai K.
  • Journal Title: Soc Neurosci. Volume: 10 Issue: 3 Pages: 230-42
  • DOI: 10.1080/17470919.2014.997370
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Psychological symptom and social functioning subscales of the modified Global Assessment of Functioning scale: reliability and validity of the Japanese version. (2015)
  • Author(s): Eguchi S, Koike S, Suga M, Takizawa R, Kasai K.
  • Journal Title: Psychiatry and Clinical Neuroscience Volume: 69(2) Issue: 2 Pages: 126-127
  • DOI: 10.1111/pcn.12250
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Similar age-related decline in cortical activity over frontotemporal regions in schizophrenia: a multichannel near-infrared spectroscopy study. (2015)
  • Author(s): Chou PH, Koike S, Nishimura Y, Satomura Y, Kinoshita A, Takizawa R, Kasai K.
  • Journal Title: Schizophrenia Bulletin Volume: 41(1) Issue: 1 Pages: 268-279
  • DOI: 10.1093/schbul/sbu086
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Health Researchのための研究デザインを学ぶ (2015)
  • Author(s): 滝沢龍
  • Journal Title: 臨床精神医学 Volume: 44(1) Pages: 131-134
  • Peer Reviewed
• [Journal Article] Adult health outcomes of childhood bullying victimization: Evidence from a 5-decade longitudinal British cohort. (2014)
  • Author(s): Ryu Takizawa, Barbara Maughan, Louise Arseneault.
  • Journal Title: American Journal of Psychiatry Volume: 171(7) Issue: 7 Pages: 777-784
  • DOI: 10.1176/appi.ajp.2014.13101401
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 統合失調症に対するニューロフィードバックの現状と展望 (2014)
  • Author(s): 木下晃秀、滝沢龍、笠井清登
  • Journal Title: 分子精神医学 Volume: 14(3) Pages: 171-179
  • Peer Reviewed
• [Journal Article] うつ症状の鑑別診断補助としての光トポグラフィー検査の有用性 (2014)
  • Author(s): 滝沢龍、福田正人．
  • Journal Title: 精神科 Volume: 25(3) Pages: 250-256
  • Peer Reviewed
• [Journal Article] NIRSによる計測される脳血流変化は何を反映しているのか (2014)
  • Author(s): 里村嘉弘、榊原英輔、滝沢龍、笠井清登
  • Journal Title: 精神科 Volume: 25(3) Pages: 290-293
  • Peer Reviewed
• [Journal Article] Anxiety and Performance: The disparate roles of prefrontal sub-regions under maintained psychological stress. (2013)
  • Author(s): Takizawa R, Nishimura Y, Yamasue H, Kasai K
  • Journal Title: Cerebral Cortex Volume: Advanced online publication Issue: 7 Pages: 1858-1866
  • DOI: 10.1093/cercor/bht036
  • Peer Reviewed
• [Presentation] Correlation of fronto-temporal cortical activity with severity and future prognosis in Major Depressive Disorder: A longitudinal functional near-infrared spectroscopy study. (2015)
  • Author(s): Yoshihiro Satomura, Ryu Takizawa, Yukika Nishimura, Shinsuke Koike, Hanako Sakurada, Mika Yamagishi, Akihide Kinoshita, Eisuke Sakakibara, Jun Matsuoka, Naohiro Okada, Shingo Kawasaki, Kiyoto Kasai.
  • Organizer: The World Psychiatric Association International Congress 2015
  • Place of Presentation: Taipei, Taiwan.
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Detection of Resting State Functional Connectivity Between Homologous Brain Regions: A Study with Multi-Distance Probe and Whole-Head Near-Infrared Spectroscopy. (2015)
  • Author(s): Eisuke Sakakibara, Fumitaka Homae, Shingo Kawasaki, Yukika Nishimura, Ryu Takizawa, et al.
  • Organizer: The World Psychiatric Association International Congress 2015.
  • Place of Presentation: Taipei, Taiwan.
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] 外来統合失調症患者に対するメタ認知訓練法． (2015)
  • Author(s): 江口聡、管心、山崎修道、滝沢龍、夏堀龍暢、吉原美沙紀、清水季実子、石橋綾、矢島明佳、株元麻美、飯田美恵、竹下保、塩原裕理、笠井清登．
  • Organizer: 日本統合失調症学会
  • Place of Presentation: 東京
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] Childhood bullying victimization predicts adult risk factors for age-related disease in a 5-decade longitudinal British cohort. (2015)
  • Author(s): Louise Arseneault, Ryu Takizawa, Barbara Maughan.
  • Organizer: Society for Research in Child Development Binnial Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] Adult Health Outcomes of Childhood Bullying Victimization (2014)
  • Author(s): Ryu Takizawa, Barbara Maughan, Louise Arseneault.
  • Organizer: The All Party Parliamentary Group (APPG) on Bullying AGM and meeting
  • Place of Presentation: The Parliament. Westminster London, UK
  • Year and Date: 2014-07-08
  • Invited
• [Presentation] The adult consequences of being bullied in childhood: Results from a 50-year prospective epidemiolocial study (2014)
  • Author(s): Barbara Maughan, Ryu Takizawa, Louise Arseneault
  • Organizer: Life History Research Society Meeting
  • Place of Presentation: Pittsburgh, USA
  • Year and Date: 2014-05-07 – 2014-05-10
• [Presentation] Childhood bullying victimization predicts adult risk factors for age-related disease in a 5-decade longitudinal British cohort (2014)
  • Author(s): Louise Arseneault, Ryu Takizawa, Barbara Maughan.
  • Organizer: Life History Research Society Meeting
  • Place of Presentation: Pittsburgh, USA
  • Year and Date: 2014-05-07 – 2014-05-10
• [Book] 公認心理師必携 精神医療・臨床心理の知識と技法（仮） (2016)
  • Author(s): 下山晴彦、中嶋義文、鈴木伸一、花村温子、滝沢龍、(編)
  • Publisher: 医学書院
• [Book] 精神疾患を理解するために－メンタルヘルス・DSM-5実践ガイドブック(仮） (2016)
  • Author(s): 滝沢 龍
  • Publisher: 医学書院
• [Book] 生活機能評価（GAF）In: 臨床評価で読み解くこころ (2015)
  • Author(s): 滝沢龍
  • Publisher: 中山書店
• [Book] 英国の双生児出生コホート研究 In:思春期学 (2015)
  • Author(s): 滝沢龍
  • Publisher: 東京大学出版会
• [Book] 個別症例における有用性と限界 In:精神疾患の脳画像ケースカンファレンス (2014)
  • Author(s): 里村嘉弘、滝沢龍
  • Publisher: 中山書店
• [Book] DSM-5 In:誠信 心理学辞典 (2014)
  • Author(s): 滝沢龍
  • Publisher: 誠信書房
• [Book] 薬物療法 In:誠信 心理学辞典 (2014)
  • Author(s): 滝沢龍
  • Publisher: 誠信書房
• [Book] 精神医学 In:誠信 心理学辞典 (2014)
  • Author(s): 滝沢龍
  • Publisher: 誠信書房