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Longitudinal Study for Brain Functions of Remission and Recovery in Mood disorders and Schizophrenia

Research Project

Project/Area Number 26860914
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

Takizawa Ryu  東京大学, 医学部附属病院, 助教 (30420243)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords統合失調症 / 気分障害 / 寛解 / 回復 / 脳機能 / 縦断的研究 / 双生児法 / ストレス / NIRS / fMRI / リカバリー / 縦断的研究法
Outline of Final Research Achievements

The main purpose of this research is to elucidate the underlying brain functions not only for ‘(symptomatic) Remission’ but also for ‘Recovery’ which includes social functioning, subjective well-being and quality of life (QOL). We showed the potential applicability of near-infrared spectroscopy (NIRS) for differential diagnosis of the patients with depressive symptoms. However, the applicability of NIRS to the assessment of symptom and prognostic prediction remains to be elucidated.
Prospectively we have measured the baseline, 1.5-year and 3-year follow-ups in healthy controls and patients. Our results showed that there is a possibility that prefrontal and temporal NIRS signals have state-dependent and trait-dependent characteristics (for symptoms, functioning and QOL) on the basis of differential brain regions. The current research has shown the potential applicability to the assessment of symptom and the establishment of prognostic prediction.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (33 results)

All 2016 2015 2014 2013

All Journal Article (18 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 18 results,  Open Access: 6 results,  Acknowledgement Compliant: 12 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (8 results)

  • [Journal Article] Association between impaired brain activity and volume at the sub-region of Broca's area in ultra-high risk and first-episode schizophrenia: a multi-modal neuroimaging study.2016

    • Author(s)
      Norichika Iwashiro, Shinsuke Koike, Yoshihiro Satomura, Motomu Suga, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Wataru Gonoi, Ryu Takizawa, Akira Kunimatsu, Hidenori Yamasue, Kiyoto Kasai
    • Journal Title

      Schizophrenia Research

      Volume: Epub ahead of print Issue: 1-3 Pages: 9-15

    • DOI

      10.1016/j.schres.2016.02.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between rostral prefrontal cortical activity and functional outcome in first-episode psychosis: a longitudinal functional near-infrared spectroscopy study.2016

    • Author(s)
      Koike S, Satomura Y, Kawasaki S, Nishimura Y, Takano Y, Iwashiro N, Kinoshita A, Nagai T, Natsubori T, Tada M, Ichikawa E, Takizawa R, Kasai K
    • Journal Title

      Schizophr Res

      Volume: 170 Issue: 2-3 Pages: 304-310

    • DOI

      10.1016/j.schres.2016.01.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial.2016

    • Author(s)
      Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y.
    • Journal Title

      Neuropsychopharmacology.

      Volume: 40 Issue: 12 Pages: 2676-2685

    • DOI

      10.1038/npp.2015.128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: an imaging genetics study using multi-channel near-infrared spectroscopy.2015

    • Author(s)
      Kinoshita A, Takizawa R, Koike S, Satomura Y, Kawasaki S, Kawakubo Y, Marumo K, Tochigi M, Sasaki T, Nishimura Y, Kasai K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 62 Pages: 13-21

    • DOI

      10.1016/j.pnpbp.2015.04.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bulllying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study.2015

    • Author(s)
      Ryu Takizawa, Andrea Danese, Barbara Maughan, Louise Arseneault.
    • Journal Title

      Psychol Med.

      Volume: 45(13) Issue: 13 Pages: 2705-2715

    • DOI

      10.1017/s0033291715000653

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: A multi-channel near-infrared spectroscopy study2015

    • Author(s)
      Okada N, Takahashi K, Nishimura Y, Koike S, Ishii-Takahashi A, Sakakibara E, Satomura Y, Kinoshita A, Takizawa R, Kawasaki S, Nakakita M, Ohtani T, Okazaki Y, Kasai K
    • Journal Title

      Addict Biol

      Volume: 21 Issue: 2 Pages: 489-503

    • DOI

      10.1111/adb.12224

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder; a randomized controlled trial.2015

    • Author(s)
      Ayaka Ishii-Takahashi, Ryu Takizawa et al.
    • Journal Title

      Neuropsychopharmacology

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A concurrent fNIRS-fMRI measurement for validation of a separation method between deep and shallow fNIRS signals with multi-distance optodes.2015

    • Author(s)
      Tsukasa Funane, Hiroki Sato, Noriaki Yahata, Ryu Takizawa, et al.
    • Journal Title

      Neurophotonics

      Volume: 2(1) Issue: 1 Pages: 015003-015003

    • DOI

      10.1117/1.nph.2.1.015003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bulllying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study.2015

    • Author(s)
      Ryu Takizawa, Andrea Danese, Barbara Maughan, Louise Arseneault
    • Journal Title

      Psychological Medicine

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Using social epidemiology and neuroscience to explore the relationship between job stress and frontotemporal cortex activity among workers2015

    • Author(s)
      Kawasaki S, Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Yoshikawa A, Inai A, Nishioka M, Eriguchi Y, Kakiuchi C, Araki T, Kan C, Umeda M, Shimazu A, Hashimoto H, Kawakami N, Kasai K.
    • Journal Title

      Soc Neurosci.

      Volume: 10 Issue: 3 Pages: 230

    • DOI

      10.1080/17470919.2014.997370

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Psychological symptom and social functioning subscales of the modified Global Assessment of Functioning scale: reliability and validity of the Japanese version.2015

    • Author(s)
      Eguchi S, Koike S, Suga M, Takizawa R, Kasai K.
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 69(2) Issue: 2 Pages: 126-127

    • DOI

      10.1111/pcn.12250

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Similar age-related decline in cortical activity over frontotemporal regions in schizophrenia: a multichannel near-infrared spectroscopy study.2015

    • Author(s)
      Chou PH, Koike S, Nishimura Y, Satomura Y, Kinoshita A, Takizawa R, Kasai K.
    • Journal Title

      Schizophrenia Bulletin

      Volume: 41(1) Issue: 1 Pages: 268-279

    • DOI

      10.1093/schbul/sbu086

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Health Researchのための研究デザインを学ぶ2015

    • Author(s)
      滝沢龍
    • Journal Title

      臨床精神医学

      Volume: 44(1) Pages: 131-134

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adult health outcomes of childhood bullying victimization: Evidence from a 5-decade longitudinal British cohort.2014

    • Author(s)
      Ryu Takizawa, Barbara Maughan, Louise Arseneault.
    • Journal Title

      American Journal of Psychiatry

      Volume: 171(7) Issue: 7 Pages: 777-784

    • DOI

      10.1176/appi.ajp.2014.13101401

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 統合失調症に対するニューロフィードバックの現状と展望2014

    • Author(s)
      木下晃秀、滝沢龍、笠井清登
    • Journal Title

      分子精神医学

      Volume: 14(3) Pages: 171-179

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] うつ症状の鑑別診断補助としての光トポグラフィー検査の有用性2014

    • Author(s)
      滝沢龍、福田正人.
    • Journal Title

      精神科

      Volume: 25(3) Pages: 250-256

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] NIRSによる計測される脳血流変化は何を反映しているのか2014

    • Author(s)
      里村嘉弘、榊原英輔、滝沢龍、笠井清登
    • Journal Title

      精神科

      Volume: 25(3) Pages: 290-293

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anxiety and Performance: The disparate roles of prefrontal sub-regions under maintained psychological stress.2013

    • Author(s)
      Takizawa R, Nishimura Y, Yamasue H, Kasai K
    • Journal Title

      Cerebral Cortex

      Volume: Advanced online publication Issue: 7 Pages: 1858-1866

    • DOI

      10.1093/cercor/bht036

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Correlation of fronto-temporal cortical activity with severity and future prognosis in Major Depressive Disorder: A longitudinal functional near-infrared spectroscopy study.2015

    • Author(s)
      Yoshihiro Satomura, Ryu Takizawa, Yukika Nishimura, Shinsuke Koike, Hanako Sakurada, Mika Yamagishi, Akihide Kinoshita, Eisuke Sakakibara, Jun Matsuoka, Naohiro Okada, Shingo Kawasaki, Kiyoto Kasai.
    • Organizer
      The World Psychiatric Association International Congress 2015
    • Place of Presentation
      Taipei, Taiwan.
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of Resting State Functional Connectivity Between Homologous Brain Regions: A Study with Multi-Distance Probe and Whole-Head Near-Infrared Spectroscopy.2015

    • Author(s)
      Eisuke Sakakibara, Fumitaka Homae, Shingo Kawasaki, Yukika Nishimura, Ryu Takizawa, et al.
    • Organizer
      The World Psychiatric Association International Congress 2015.
    • Place of Presentation
      Taipei, Taiwan.
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外来統合失調症患者に対するメタ認知訓練法.2015

    • Author(s)
      江口聡、管心、山崎修道、滝沢龍、夏堀龍暢、吉原美沙紀、清水季実子、石橋綾、矢島明佳、株元麻美、飯田美恵、竹下保、塩原裕理、笠井清登.
    • Organizer
      日本統合失調症学会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Childhood bullying victimization predicts adult risk factors for age-related disease in a 5-decade longitudinal British cohort.2015

    • Author(s)
      Louise Arseneault, Ryu Takizawa, Barbara Maughan.
    • Organizer
      Society for Research in Child Development Binnial Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Adult Health Outcomes of Childhood Bullying Victimization2014

    • Author(s)
      Ryu Takizawa, Barbara Maughan, Louise Arseneault.
    • Organizer
      The All Party Parliamentary Group (APPG) on Bullying AGM and meeting
    • Place of Presentation
      The Parliament. Westminster London, UK
    • Year and Date
      2014-07-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The adult consequences of being bullied in childhood: Results from a 50-year prospective epidemiolocial study2014

    • Author(s)
      Barbara Maughan, Ryu Takizawa, Louise Arseneault
    • Organizer
      Life History Research Society Meeting
    • Place of Presentation
      Pittsburgh, USA
    • Year and Date
      2014-05-07 – 2014-05-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Childhood bullying victimization predicts adult risk factors for age-related disease in a 5-decade longitudinal British cohort2014

    • Author(s)
      Louise Arseneault, Ryu Takizawa, Barbara Maughan.
    • Organizer
      Life History Research Society Meeting
    • Place of Presentation
      Pittsburgh, USA
    • Year and Date
      2014-05-07 – 2014-05-10
    • Related Report
      2014 Research-status Report
  • [Book] 公認心理師必携 精神医療・臨床心理の知識と技法(仮)2016

    • Author(s)
      下山晴彦、中嶋義文、鈴木伸一、花村温子、滝沢龍、(編)
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 精神疾患を理解するために-メンタルヘルス・DSM-5実践ガイドブック(仮)2016

    • Author(s)
      滝沢 龍
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 生活機能評価(GAF)In: 臨床評価で読み解くこころ2015

    • Author(s)
      滝沢龍
    • Publisher
      中山書店
    • Related Report
      2014 Research-status Report
  • [Book] 英国の双生児出生コホート研究 In:思春期学2015

    • Author(s)
      滝沢龍
    • Publisher
      東京大学出版会
    • Related Report
      2014 Research-status Report
  • [Book] 個別症例における有用性と限界 In:精神疾患の脳画像ケースカンファレンス2014

    • Author(s)
      里村嘉弘、滝沢龍
    • Publisher
      中山書店
    • Related Report
      2014 Research-status Report
  • [Book] DSM-5 In:誠信 心理学辞典2014

    • Author(s)
      滝沢龍
    • Publisher
      誠信書房
    • Related Report
      2014 Research-status Report
  • [Book] 薬物療法 In:誠信 心理学辞典2014

    • Author(s)
      滝沢龍
    • Publisher
      誠信書房
    • Related Report
      2014 Research-status Report
  • [Book] 精神医学 In:誠信 心理学辞典2014

    • Author(s)
      滝沢龍
    • Publisher
      誠信書房
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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