Investigation of the mechanism for and psychiatric symptoms due to elevation of inflammatory cytokines in mood disorders.
Project/Area Number |
26860946
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | うつ病 / 気分障害 / サイトカイン / 酸化ストレス / 動物モデル / 炎症性サイトカイン / HHV-6 / 疲労 / モデルマウス / SITH-1 / 双極性障害 |
Outline of Final Research Achievements |
The study aimed to clarify the mechanism for the elevation of inflammatory cytokines, and the psychiatric symptoms produced by it, in major depressive disorder (MDD) through clinical investigation and the use of an animal model. However, in this study there were no significant differences in inflammatory cytokines between MDD patients and normal controls (NC). On the other hand, the oxidative stress marker was more elevated in MDD patients than NC. Transgenic (Tg) mice with regulated expression of SITH-1 (the latent protein of human herpesvirus 6) were prepared. Although the Tg mice showed depressive-like behavior compared to wild-type mice, there was no significant association between SITH-1 and the inflammatory cytokine.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers inDiagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.2016
Author(s)
Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.
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Journal Title
PloS one
Volume: 11
Issue: 12
Pages: e0168816-e0168816
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study.2016
Author(s)
Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.
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Journal Title
International Journal of Geriatric Psychiatry
Volume: 4
Issue: 12
Pages: 1241-1246
DOI
Related Report
Peer Reviewed
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[Journal Article] Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue.2016
Author(s)
Aoki, R., Kobayashi, N., Suzuki, G., Kuratsune, H., Shimada, K., Oka, N., Takahashi, M., Yamadera, W., Iwashita, M., Tokuno, S., Nibuya, M., Tanichi, M., Mukai, Y., Mitani, K., Kondo, K., Ito, H., Nakayama, K.
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Journal Title
Biochem. Biophy. Res. Commun.
Volume: 478
Issue: 1
Pages: 424-430
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer’s Disease and Amnesic Mild Cognitive Impairment.2016
Author(s)
Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo.
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Journal Title
PLoS ONE
Volume: 11(1)
Issue: 1
Pages: e0146449-e0146449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease2015
Author(s)
Nagata T, Kobayashi N, Ishii J, Shinagawa S, Nakayama R, Shibata N, Kuerban B, Ohnuma T, Kondo K, Arai H, Yamada H, Nakayama K
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Journal Title
Dement Geriatr Cogn Dis Extra
Volume: 5
Issue: 1
Pages: 64-73
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Human herpesvirus 6 (HHV-) and HHV-7 reactivation in fatigue, which distinguishes between physiological fatigue and pathological fatigue.2016
Author(s)
Nobuyuki Kobayashi, Ryo Aoki, Hirohiko Kuratsune, Naomi Oka, Mayumi Takahashi, Kazuya Shimada, Wataru Yamadera, Masayuki Iwashita, Hiroshi Ito, Kazuhiko Nakayama, Kazuhiro Kondo.
Organizer
第64回日本ウイルス学会 (The 64th Annual Meeting of the Japanese Society for Virology)
Place of Presentation
札幌
Year and Date
2016-10-24
Related Report
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[Presentation] 血液中DNAメチル化変化を利用したアルツハイマー病と軽度認知機能障害の新規診断法に関する検討.2016
Author(s)
小林伸行, 品川俊一郎, 永田智行, 嶋田和也, 柴田展人, 大沼徹, 笠貫浩史, 新井平伊, 山田尚, 中山和彦, 近藤一博.
Organizer
第31回日本老年精神医学会
Place of Presentation
金沢
Year and Date
2016-06-23
Related Report
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[Presentation] 唾液中ヒトヘルペスウイルス(HHV-)6及びHHV-7量による病的疲労と生理的疲労との鑑別に関する検討.2016
Author(s)
小林伸行, 青木亮, 岡直美, 髙橋麻弓, 嶋田和也, 玉井将人, 山寺亘, 岩下正幸, 倉恒弘彦, 伊藤洋, 中山和彦, 近藤一博.
Organizer
第12回日本疲労学会
Place of Presentation
横浜
Year and Date
2016-05-20
Related Report
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