Development of the sigma-2 receptor imaging agent for the purpose of early detection and the proliferation potency diagnosis of the solid tumor
| Project/Area Number |
26860987
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
Kozaka Takashi 金沢大学, 学際科学実験センター, 助教 (50579836)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | σ-2受容体 / vesamicol / 分子イメージング / イメージング |
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| Outline of Final Research Achievements |
Expression of sigma-2 receptor is seen in many kinds of solid tumor cell, such as breast cancer and the pancreatic cancer, and sigma-2 receptor of up to 10 times overexpressed in the proliferation period. In other words, sigma-2 receptor was important biomarker of the solid tumor cell for the proliferation period, and sigma-2 receptor imaging is estimated to possess the possibility for early detection and the increase ability diagnosis of cancer. [125I]PIDV, which I developed in this study, showed superior sigma-2 receptor accumulation in in vitro and in vivo and [123I]PIDV worked successfully in sigma-2 receptor imaging with tumor-bearing mouse (human breast adenocarcinoma cell line MCF-7) by the SPECT.
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Report
(4 results)
Research Products
(13 results)
