Functional image-guided dosimetric evaluation for the radiotherapy treatment planning of liver tumors
Project/Area Number |
26861004
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kumamoto University |
Principal Investigator |
TOYA Ryo 熊本大学, 医学部附属病院, 講師 (60452893)
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Research Collaborator |
NAMIMOTO Tomohiro
SHIRAISHI Shinya
FUKUGAWA Yoshiyuki
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 放射線治療 / 定位放射線治療 / 分子イメージング / 機能画像 / 画像誘導放射線治療 / 低侵襲治療 / 放射線肝障害 / 線量体積ヒストグラム / 肝腫瘍 / 肝硬変 / オーダーメイド治療 / 放射線治療計画 / オーダーメード治療 |
Outline of Final Research Achievements |
We introduced functional images into dosimetric evaluation for the radiotherapy treatment planning of liver tumors. We evaluated hepatocellular carcinoma (HCC) patients treated with stereotactic radiotherapy of 30-40 Gy in five fractions. We calculated dose-function histogram parameters based on 99mTc-GSA SPECT/CT images and found that the history of prior treatment significantly influenced on the parametric discrepancy between dose-function and dose-volume histogram. We also evaluated HCC patients treated with 3D-conformal radiotherapy of 45 Gy in 15 fractions. We investigated the relationship between radiotherapy dose and focally decreased enhancement of Gd-EOB-DTPA-enhanced MRI. The threshold dose was approx. 35 Gy. Our results may facilitate the precise prediction for the radiation-induced liver disease.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Tumor motion changes in stereotactic body radiotherapy for liver tumors: an evaluation based on four-dimensional cone-beam computed tomography and fiducial markers2017
Author(s)
Shimohigashi Y*, Toya R, Saito T, Ikeda O, Maruyama M, Yonemura K, Nakaguchi Y, Kai Y, Yamashita Y, Oya N, Araki F
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Journal Title
Radiat Oncol
Volume: 12
Issue: 1
Pages: 61-61
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Radiation therapy for nasopharyngeal carcinoma: Predictive value of interim survival assessment2016
Author(s)
Toya R, Murakami R, Saito T, Murakami D, Matsuyama T, Baba Y, Nishimura R, Hirai T, Semba A, Yumoto E, Yamashita Y, Oya N
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Journal Title
Related Report
Peer Reviewed / Open Access
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