Functional image-guided dosimetric evaluation for the radiotherapy treatment planning of liver tumors

• Project/Area Number: 26861004
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: TOYA Ryo 熊本大学, 医学部附属病院, 講師 (60452893)
• Research Collaborator: NAMIMOTO Tomohiro ; SHIRAISHI Shinya ; FUKUGAWA Yoshiyuki
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 放射線治療 / 定位放射線治療 / 分子イメージング / 機能画像 / 画像誘導放射線治療 / 低侵襲治療 / 放射線肝障害 / 線量体積ヒストグラム / 肝腫瘍 / 肝硬変 / オーダーメイド治療 / 放射線治療計画 / オーダーメード治療

Outline of Final Research Achievements

We introduced functional images into dosimetric evaluation for the radiotherapy treatment planning of liver tumors. We evaluated hepatocellular carcinoma (HCC) patients treated with stereotactic radiotherapy of 30-40 Gy in five fractions. We calculated dose-function histogram parameters based on 99mTc-GSA SPECT/CT images and found that the history of prior treatment significantly influenced on the parametric discrepancy between dose-function and dose-volume histogram. We also evaluated HCC patients treated with 3D-conformal radiotherapy of 45 Gy in 15 fractions. We investigated the relationship between radiotherapy dose and focally decreased enhancement of Gd-EOB-DTPA-enhanced MRI. The threshold dose was approx. 35 Gy. Our results may facilitate the precise prediction for the radiation-induced liver disease.

Research Products

• [Int'l Joint Research] University of Wisconsin(米国)
• [Int'l Joint Research] University of Wisconsin(米国)
• [Journal Article] Radiation-induced Liver Injury after 3D-conformal Radiotherapy for Hepatocellular Carcinoma: Quantitative Assessment Using Gd-EOB-DTPA-enhanced MRI (2017)
  • Author(s): Fukugawa Y, Namimoto T, Toya R*, Saito T, Yuki H, Matsuyama T, Ikeda O, Yamashita Y, Oya N
  • Journal Title: Acta Medica Okayama Volume: 71 Issue: 1 Pages: 25-29
  • DOI: 10.18926/AMO/54822
  • NAID: 120005971552
  • URL: https://ousar.lib.okayama-u.ac.jp/54822
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tumor motion changes in stereotactic body radiotherapy for liver tumors: an evaluation based on four-dimensional cone-beam computed tomography and fiducial markers (2017)
  • Author(s): Shimohigashi Y*, Toya R, Saito T, Ikeda O, Maruyama M, Yonemura K, Nakaguchi Y, Kai Y, Yamashita Y, Oya N, Araki F
  • Journal Title: Radiat Oncol Volume: 12 Issue: 1 Pages: 61-61
  • DOI: 10.1186/s13014-017-0799-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Radiation therapy for nasopharyngeal carcinoma: Predictive value of interim survival assessment (2016)
  • Author(s): Toya R, Murakami R, Saito T, Murakami D, Matsuyama T, Baba Y, Nishimura R, Hirai T, Semba A, Yumoto E, Yamashita Y, Oya N
  • Journal Title: J Radiat Res Volume: 未定
  • Peer Reviewed / Open Access
• [Journal Article] Respiratory Gating during Stereotactic Body Radiotherapy for Lung Cancer Reduces Tumor Position Variability (2014)
  • Author(s): Tetsuo Saito, Tomohiko Matsuyama, Ryo Toya, Yoshiyuki Fukugawa, Takamasa Toyofuku, Akiko Semba, Natsuo Oya
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e112824-e112824
  • DOI: 10.1371/journal.pone.0112824
  • Peer Reviewed / Open Access
• [Presentation] 肝細胞癌に対する定位放射線治療における99mTc-GSA SPECT/CTを用いた機能線量体積評価 (2017)
  • Author(s): 東家亮、斉藤哲雄、白石慎哉、甲斐祐大、 松山知彦、下東吉信、山下康行、大屋夏生
  • Organizer: 第30回高精度放射線外部照射部会学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-08
• [Presentation] Radiation Induced Liver Injury after 3D-conformal Radiotherapy for Hepatocellular Carcinoma: Quantitative Assessment by Gd-EOB-DTPA-Enhanced MRI (2016)
  • Author(s): Toya R, Fukugawa Y, Namimoto T, Saito T, Yuki H, Matsuyama T, Ikeda O, Yamashita Y, Oya N
  • Organizer: 58th Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: Boston, MA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Evaluation of Interfractional and Intrafractional Tumor Motion in Stereotactic Liver Radiotherapy, Based On Four-Dimentional Cone-Beam Computed Tomography Using Fiducial Markers (2016)
  • Author(s): Shimohigashi Y, Araki F, Toya R, Maruyama M, Nakaguchi Y
  • Organizer: 58th Annual Meeting and Exhibition of American Association of Physicists in Medicine
  • Place of Presentation: Washington, DC
  • Year and Date: 2016-07-31
  • Int'l Joint Research
• [Presentation] Implications for Online Adaptive and Non-Adaptive Radiotherapy of Gastric and Gastroesophageal Junction Cancers Using MRI-Guided Radiothrapy (2016)
  • Author(s): Mittauer K, Geurts M, Toya R, Bassetti M, Harari P, Paliwal B, Bayouth J
  • Organizer: 58th Annual Meeting and Exhibition of American Association of Physicists in Medicine
  • Place of Presentation: Washington, DC
  • Year and Date: 2016-07-31
  • Int'l Joint Research
• [Presentation] T3 Squamous Cell Carcinoma of the Glottic Larynx (2016)
  • Author(s): Wojcieszynski A P, Toya R, Hartig G K, McCulloch T M, Britt C, Gessert T, Avey G D, Harari P M
  • Organizer: Multidisciplinary head and neck cancer symposium
  • Place of Presentation: Scottsdale, AZ
  • Year and Date: 2016-02-18
  • Int'l Joint Research
• [Presentation] Pattern of Lymph Node Involvement and Prognosis in Patients With Stage III-IV Oral Cancer Treated With Concurrent Chemoradiation Therapy (2015)
  • Author(s): Murakami R, Nakayama H, Toya R, Hiraki A, Nagata M, Kawahara K, Hirai T, Yamashita Y
  • Organizer: 57th Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: San Antonio, TX
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Assessment of the Neck Node Levels in Patients With Hypopharyngeal Carcinoma (2015)
  • Author(s): Semba A, Murakami R, Murakami D, Toya R, Hirai T, Saito T, Matsuyama T, Toyofuku T, Oya N
  • Organizer: 57th Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: San Antonio, TX
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Palliative Radiation Therapy for Painful Tumors With and Without Neuropathic Components (2015)
  • Author(s): Toyofuku T, Saito T, Toya R, Semba A, Fukugawa Y, Matsuyama T, Oya N
  • Organizer: 57th Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: San Antonio, TX
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Improved Cancer Pain Management After Radiation Therapy for Painful Tumors (2015)
  • Author(s): Toyofuku T, Saito T, Toya R, Semba A, Fukugawa Y, Matsuyama T, Oya N
  • Organizer: 57th Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: San Antonio, TX
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Sequential Change of Radiation Dose Distribution within Target Volume and Organ at Risk in Postoperative Irradiation of Glioblastomas (2015)
  • Author(s): Matsuyama T, Fukugawa Y, Toya R, Toyofuku T, Semba A, Saito T, Oya N
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 肝腫瘍に対する定位放射線治療の初期経験 (2015)
  • Author(s): 小笠原浩司、東家亮、斉藤哲雄、福川喜之、仙波明子、 松山知彦、大屋夏生、池田理、田村吉高、山下康行
  • Organizer: 第180回日本医学放射線学会九州地方会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県福岡市）
  • Year and Date: 2015-02-14 – 2015-02-15