Evaluation of oxidative stress in the brain of a mouse model of Alzheimer disease by in vivo EPR imaging system.
Project/Area Number |
26861008
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Sapporo Medical University |
Principal Investigator |
Emoto Miho 札幌医科大学, 医療人育成センター, 研究員 (10578735)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | EPRイメージング / アルツハイマー病モデルマウス / 酸化ストレス / エイジング / EPRイメージング法 / レドックスバランス |
Outline of Final Research Achievements |
Alzheimer’s disease (AD) is a neurodegenerative disease clinically characterized by progressive cognitive dysfunction. Deposition of amyloid-β (Aβ) peptides is the most important pathophysiological hallmark of AD. Oxidative stress induced by reactive oxygen species (ROS) is prominent in AD, and several reports suggest the relationship between the change in redox status and AD pathology containing progressive Aβ deposition. electron paramagnetic resonance (EPR) imaging is used to acquire spatial information about the distribution of free radical species in vivo and visualize oxidative stress derived from ROS. in vivo changes in redox status with age in both wild-type (WT) and AD mouse brains were measured noninvasively by three-dimensional (3D) EPR imaging using nitroxide (MCP) as a redox-sensitive probe. EPR imaging clearly visualized the accelerated change in redox status of AD mouse brain compared with WT.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging.2015
Author(s)
Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H,Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S.
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Journal Title
Free Radic Biol Med.
Volume: 85
Pages: 165-173
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Synthesis of ^<15>N-labeled 4-oxo-2,2, 6,6-tetraethylpiperidine nitroxide for EPR brain imaging2014
Author(s)
Xiaolei Wang, Miho Emoto, Atsushi Sugimoto, Yusuke Miyake, Kaori Itto, Mitsuo Amasaka, Shu Xu, Hiroshi Hirata, Hirotada Fuji, Hirokazu Arimoto
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Journal Title
Tetrahedron Letters
Volume: 55
Issue: 13
Pages: 2146-2149
DOI
Related Report
Peer Reviewed
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