The prediction of results of radiotherapy with expression of proteins involved with DNA repair
| Project/Area Number |
26861010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射線治療 / 前立腺癌 / DNA修復 |
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| Outline of Final Research Achievements |
We investigated the relationship between the expression of proteins involved with NHEJ and results of radiotherapy for prostate cancers. One hundred patients were treated with radiotherapy between March 2001 and October 2010. Formalin-fixed, paraffin-embedded specimens from pretreatment needle biopsy were assessed for Ku70, Ku86 and XRCC4. The number of cells that stained positive for Ku70, Ku86 and XRCC4 were determined the percentages of cells that were positive for the expression of Ku70, Ku86 and XRCC4. Of the 100 patients, 23 experienced biochemical failure. On univariate analysis, irradiation method, radiation dose and the expression of Ku70 had the significance for biochemical failure. On multivariate analysis, irradiation method, gleason score and the expression of Ku70 were significant independent prognostic factors for biochemical recurrence. The higher expression of Ku70 indicated the significantly deteriorated PSA relapse in radiotherapy of prostate cancer.
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Report
(3 results)
Research Products
(2 results)
