To investigate the influence of the specific gravity change of ethiodized oil on its distribution after arterial injection in the in-vivo model.
| Project/Area Number |
26861017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Keio University |
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Principal Investigator |
Tsukada Jitsuro 慶應義塾大学, 医学部(信濃町), 助教 (50573276)
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| Research Collaborator |
Nakatsuka Seishi
Inoue Masanori
Ito Nobutake
Misu Manabu
Toyama Kenji
Narimatsu Hidetoshi
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 油性造影剤 / 比重変化 / リピオドール / NBCA / 生体内分布 / 比重 / 組織内分布 / 肝動脈化学塞栓術 / n-butyl 2-cyanoacrylate / 粘性度評価 |
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| Outline of Final Research Achievements |
As a result of our in vitro studies, a suspension made of an isobaric ethiodized oil contrast medium adjusted to have an equal specific gravity as human blood has lower viscosity than the suspension made of a high specific gravity oil contrast medium so that it might be a useful material for the transcatheter arterial chemoembolization or the hepatic arterial infusion chemotherapy for primary hepatocellular carcinoma or metastatic hepatic tumors.
In addition, our in vivo studies showed that isobaric ethiodized oil contrast medium was less effected the gravity effect and more evenly distributed after arterial injection compared with conventional high specific gravity oil contrast medium.
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Report
(5 results)
Research Products
(1 results)
