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Orthotopic mouse model of gastric cancer which reliably develops CTC

Research Project

Project/Area Number 26861042
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

IWATA Naoki  名古屋大学, 医学部附属病院, 助教 (00719247)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCirculating Tumor Cell / 食道癌 / 胃癌 / 大腸癌 / CirculatingTumorCell
Outline of Final Research Achievements

Three gastric cancer cell lines (MKN1, KATO-III and MKN-45) were injected into the gastric wall of BALB/c-nu and NOD-scid mice. However, we could not find any primary tumor on gastric wall. To establish a mouse model with reproducible development of liver metastasis we used NOD-scid mice and 1x10 to the power of 6 (MKN1) were injected via portal vein. All mice developed liver metastasis. However, none of the mice had detectable Circulating Tumor Cells (CTC).
We could not established an orthotopic mouse model of gastric cancer which reliably develops CTC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Significance of SYT8 For the Detection, Prediction, and Treatment of Peritoneal Metastasis From Gastric Cancer.2017

    • Author(s)
      Mitsuro Kanda, Dai Shimizu, Haruyoshi Tanaka, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Naoki Iwata, Yukiko Niwa, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Kenta Murotani, Michitaka Fujiwara, Yasuhiro Kodera
    • Journal Title

      Annals of Surgery

      Volume: 印刷中 Issue: 3 Pages: 495-503

    • DOI

      10.1097/sla.0000000000002096

    • NAID

      120006496425

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規胃癌腹膜播種関連分子の同定と、その診断的および治療的意義に関する検討2017

    • Author(s)
      神田光郎,清水 大,田中晴祥,小林大介,田中千恵,高見秀樹,林 真路,岩田直樹,丹羽由紀子,山田 豪,藤井 努,中山吾郎,杉本 博行,小池聖彦,藤原道隆,小寺泰弘
    • Organizer
      第13回日本消化管学会総会学術集会
    • Place of Presentation
      名古屋国斉会議場(愛知県・名古屋市熱田区)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胃癌腹膜播種特異的関連分子の発現、機能および5-FU感受性への影響に関する検討2017

    • Author(s)
      神田光郎,田中晴祥,田中千恵,小林大介,岩田直樹,山田 豪,中 山吾郎,藤井 努,杉本博行,小池聖彦,藤原道隆,小寺泰弘
    • Organizer
      第50回制癌剤適応研究会
    • Place of Presentation
      ホテルクレメント徳島(徳島県・徳島市寺島本町)
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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