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The molecular mechanism of STAT3 in vascular smooth muscle cells in suppressing aortic dissection

Research Project

Project/Area Number 26861116
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionKurume University

Principal Investigator

HIRAKATA SAKI  久留米大学, 医学部, 助教 (60597425)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血管外科学 / 大動脈解離 / 分子生物学 / 血管
Outline of Final Research Achievements

In the tissue of aortic dissection, STAT3 is activated in vascular smooth muscle cells (VSMCs). By examination of mouse model of aortic dissection using genetically modified mice, we found out that activation of STAT3 in VSMCs suppress aortic dissction. By the analysis of aortic dissction tissue, we found out that inflammatory response occurs before the onset of dissection, and also that STAT3 activation inVSMCs promotes collagen fiber increase, adventitial reinforcement and protects the aortic wall by reinforcing the extracellular matrix structure of the aortic wall, and, as for
suppress aortic dissection. We conitue researching about the detailed mechanism including molecules sequentially.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (15 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] FDG-PET/CT images during 5 years before acute aortic dissection2016

    • Author(s)
      Nobuhiro Tahara, Saki Hirakata, Kota Okabe, Atsuko Tahara, Akihiro Honda, Sachiyo Igata, Hayato Kaida, Tohi Abe, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
    • Journal Title

      European Heart Journal

      Volume: 37巻10号 Issue: 24 Pages: 1933-1933

    • DOI

      10.1093/eurheartj/ehw075

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] STAT3 in vascular smooth muscle cells protects aorta from dissection by reinforcing aortic wall2015

    • Author(s)
      Saki Hirakata, Hiroki Aoki, Michihide Nishihara, Satoko Ohno, Aya Furusho, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      American Heart Association Scientific sessions 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stat3 in vascular smooth muscle cells protects aorta from dissection2015

    • Author(s)
      Saki Hirakata, Hiroki Aoki, Michihide Nishihara, Satoko Ohno, Aya Furusho, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      European Society Of Cardiology 2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of macrophage STAT3 signaling in pathogenesis of aortic dissection2015

    • Author(s)
      Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      European Society Of Cardiology 2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Excessive sodium intake worsens aortic dissection via IL-17 pathway2015

    • Author(s)
      Norifumi Nishida, Hiroki Aoki, Michihide Nishihara, Satoko Ohno, Aya Furusho, Saki Hirakata, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      European Society Of Cardiology 2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protective role of STAT3 in vascular smooth muscle cells during the development of acute aortic dissection2015

    • Author(s)
      Saki Hirakata, Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society 2015
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Molecular Pathogenesis of Aortic Dissection: Macrophage-mediated Changes in Vascular Smooth Muscle-specific Gene Expression2015

    • Author(s)
      Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society 2015
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] B Cells and Immunoglobulin Promotes Development of Abdominal Aortic Aneurys2015

    • Author(s)
      Aya Furusho, Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society 2015
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Excessive Sodium Intake Exacerbates Aortic Dissection through IL-17 Pathway2015

    • Author(s)
      Norifumi Nishida, Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Sohei Ito, Makiko Hayashi, Yoshihiro Fukumoto
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society 2015
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Protective role of STAT3 in vascular smooth muscle cells during the development of acute aortic dissection2014

    • Author(s)
      Saki Hirakata, Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      The 31st Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Protective role of STAT3 in vascular smooth muscle cells during the development of acute aortic dissection2014

    • Author(s)
      Saki Hirakata, Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      American Heart Association Scientific sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] A Common Gene Network Governs the Cellular Phenotypes in Acute Aortic Dissection2014

    • Author(s)
      Satoko Ohno, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      American Heart Association Scientific sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] The Role of B Cells in Pathogenesis of Abdominal Aortic Aneurysm2014

    • Author(s)
      Aya Furusho, Hiroki Aoki, Michihide Nishihara, Satoko Ohno, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      European Society Of Cardiology 2014
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Molecular determinant of the development of acute aortic dissection2014

    • Author(s)
      Satoko Ohno, Hiroki Aoki , Michihide Nishihara , Aya Furusho , Saki Hirakata , Norifumi Nishida , Sohei Ito , Yoshihiro Fukumoto
    • Organizer
      European Society Of Cardiology 2014
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Involvement of B cells in Pathogenesis of Abdominal Aortic Aneurysm2014

    • Author(s)
      Aya Furusho, Hiroki Aoki, Michihide Nishihara, Satoko Ohno, Saki Hirakata, Norifumi Nishida, Sohei Ito, Yoshihiro Fukumoto
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      みやこめっせ(京都)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Involvement of Macrophage Cytokine Signaling in Acute Aortic Dissection2014

    • Author(s)
      Satoko Ohno, Hiroki Aoki , Michihide Nishihara , Aya Furusho , Saki Hirakata , Norifumi Nishida , Sohei Ito , Yoshihiro Fukumoto
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      みやこめっせ(京都)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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