Prevention of reperfusion injury and hemorrhagic infarction after acute recanalization threpy for cerebral infarction using TEMPO-RNP
Project/Area Number |
26861139
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | University of Tsukuba |
Principal Investigator |
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Research Collaborator |
NAGASAKI Yukio 筑波大学, 数理物質科学研究科, 教授
HIRAYAMA Aki 筑波技術大学保健科学部, 東西医学統合医療センター, 教授
TSURUSHIMA Hideo 筑波大学, 医学医療系, 准教授
TSURUTA Wataro 虎ノ門病院, 脳神経血管内治療科
SUZUKI Kensuke 獨協医科大学, 越谷病院医学部, 教授
MATSUMARU Yuji 筑波大学, 医学医療系, 教授
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 准教授
松村 明 筑波大学, 医学医療系, 副学長
PUENTES Sandra 筑波大学, システム情報系, 助教
MATSUI Fumihiro 筑波大学, 医学医療系, 講師
HOSOO Hisayuki 筑波大学, 人間総合科学研究科
MUJAGIC Arnela 筑波大学, 人間総合科学研究科
ITO Hiromu 筑波大学, 人間総合科学研究科
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 脳虚血再灌流障害 / 脳動脈閉塞症 / 脳梗塞 / 脳神経血管ユニット保護 / RNP / ナノ粒子 / フリーラジカル消去剤 / 再開通療法 / 活性酸素 / 活性酸素消去剤 / 脳保護 / TEMPO-RNP / 脳神経・血管保護 / 血液脳関門 / 酸化ストレス / 出血性脳梗塞 / DDS化フリーラジカル消去剤 / 脳神経・血管内皮保護作用 |
Outline of Final Research Achievements |
Acute recanalization therapy is an important treatment for cerebral artery occlusion, but cerebral ischemia-reperfusion injury could cause a deterioration of cerebral infarction. We investigated neuro-endothelial unit protection effect of TEMPO-RNP (nitroxide radical-containing nanoparticles) for cerebral reperfusion injury in mice. Transient MCAO model mice received RNP or PBS through the common carotid artery. We revealed that intra-arterial TEMPO-RNP treatment decreased cerebral infarct size, protected neuronal cells and the BBB from reperfusion injury. RNP was detected on the endothelial cells and around the neuronal cells in the ischemic area. These results suggested that RNP could permeate the BBB at the first pass, remain in the ischemic area, and show ROS scavenging and neuro-endothelial unit protection effectively when injected intra-arterially.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] The voluntary driven exoskeleton Hybrid Assistive Limb (HAL) for postoperative training of thoracic ossification of the posterior longitudinal ligament: a case report.2016
Author(s)
Fujii K, Abe T, Kubota S, Marushima A, Kawamoto H, Ueno T, Matsushita A, Nakai K, Saotome K, Kadone H, Endo A, Haginoya A, Hada Y, Matsumura A, Sankai Y, Yamazaki M
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Journal Title
J Spinal Cord Med
Volume: 9
Pages: 1-7
Related Report
Peer Reviewed
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[Journal Article] Gait training of subacute stroke patients using a hybrid assistive limb: a pilot study.2016
Author(s)
Mizukami M, Yoshikawa K, Kawamoto H, Sano A, Koseki K, Asakwa Y, Iwamoto K, Nagata H, Tsurushima H, Nakai K, Marushima A, Sankai Y, Matsumura A
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Journal Title
Disabil Rehabil Assist Technol
Volume: 26
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Improvement of walking ability using Hybrid Assistive Limb training in a patient with severe thoracic myelopathy caused by ossification of the posterior longitudinal ligament. A case report2016
Author(s)
Shigeki Kubota, Tetsuya Abe, Kengo Fujii, Aiki Marushima, Tomoyuki Ueno, Ayumu Haginoya, Ayumu Endo, Hideki Kadone, Hiroaki Kawamoto, Yukiyo Shimizu, Yasushi Hada, Akira Matsumura, Yoshiyuki Sankai, Masashi Yamazaki
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Journal Title
Journal of Spine
Volume: 未定
Related Report
Peer Reviewed
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[Presentation] 活性酸素消去剤封入ナノ粒子(RNP)による脳虚血再灌流障害に対するNeurovascular unit保護効果.2016
Author(s)
丸島愛樹, 細尾久幸, 長崎幸夫, 平山暁, SandraPuentes, 伊藤 紘, 庭野亜美, 鶴嶋英夫, 鶴田和太郎, 鈴木謙介, 松井裕史, 松丸祐司, 山本哲哉, 松村 明
Organizer
第59回日本脳循環代謝学会
Place of Presentation
徳島徳島市
Related Report
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[Presentation] Neurovasular Unit Protection Using Nitroxide-Radicals Containing Nanoparticles (RNP) for Cerebral Ischemia-Reperfusion Injury2016
Author(s)
Hosoo H, Marushima A, Nagasaki Y, Hirayama A, Ito H, Puentes S, Tsurushima H, Tsuruta W, Matsui H, Suzuki K, Yamamoto T, Matsumura A
Organizer
13th International Symposium on Thrombolysis Thrombectomy and Acute Stroke Therapy
Place of Presentation
兵庫県神戸市
Related Report
Int'l Joint Research
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[Presentation] 脳脊髄疾患急性期に対するロボットスーツHALによる機能回復治療 -A feasibility and safety study-2015
Author(s)
丸島 愛樹, 河本 浩明, 松下 明, 上野 友之, 五月女 康作, 中井 啓, 門根秀樹, 伊藤 嘉朗, 鶴田 和太郎, 遠藤 歩, 羽田 康司, 滝川 知司, 鶴嶋 英夫, 水谷 太郎, 山崎 正志, 山本 哲哉, 松村 明
Organizer
第74回日本脳神経外科学会学術総会
Place of Presentation
札幌 ロイトン札幌
Year and Date
2015-10-14
Related Report
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