| Project/Area Number |
26861158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 脳脊髄液漏出症 / 脳脊髄液減少症 / 低髄液圧症 / 画像診断 / MRI / CTミエログラフィー / 脳槽シンチグラフィー / ブラッドパッチ |
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| Outline of Final Research Achievements |
Good results were obtained by conservative treatment or epidural autologous blood injection therapy (Epidural Blood patch) for cases diagnosed with cerebrospinal fluid leakage based on “Diagnostic imaging criteria for cerebrospinal fluid leakage”. Although it is not always easy to identify the site of cerebrospinal fluid leakage, the therapeutic effect was high if cerebrospinal fluid leakage could be properly diagnosed.In addition, in all cases diagnosed with cerebrospinal fluid leakage, floating dural sac sign (FDSS) was recognized on spinal cord MRI, and this finding was reduced and disappeared accompany with improvement of symptoms after treatment. The FDSS was considered to be a useful sign for diagnosis of cerebrospinal fluid leakage.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究においても脳脊髄液漏出症に対するブラッドパッチの有効性と安全性が示された。平成28年4月よりブラッドパッチが保険適用となり、今後脳脊髄液漏出症の正確な診断が求められている中で、「脳脊髄液漏出症の画像判定基準・画像診断基準」に則った検査において診断を行うことが重要であると思われた。また診断基準に含まれていないFDSSが脳脊髄液漏出症と診断された全ての症例で認められ、今後の診断の一助になる可能性が考えられた。
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