Bone fusion of autograft treated with liquid nitrogen for spinal tumor surgery

• Project/Area Number: 26861175
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kanazawa University
• Principal Investigator: Yoshioka Katsuhito 金沢大学, 医薬保健学総合研究科, 特任助教 (30525043)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 液体窒素処理骨 / 脊椎腫瘍骨全摘術 / 骨癒合 / 腫瘍脊椎骨全摘術

Outline of Final Research Achievements

It has been reported that tumor cells were completely killed by freezing in liquid nitrogen for 20 minutes. We packed autograft treated with liquid nitrogen or fresh auto graft into a cage used for vertebral body reconstruction in canine experiment. Fusion results of the autograft treated with liquid nitrogen group were nearly identical to the fresh autologous group. Therefore, autograft treated with liquid nitrogen is as beneficial as fresh autograft for total en bloc spondylectomy for spinal tumor.

Research Products

• [Presentation] 液体窒素処理骨を用いた椎体再建における骨形成過程の組織学的検討 (2015)
  • Author(s): 新村和也, 村上英樹, 出村諭, 加藤仁志, 吉岡克人, 林寛之, 井上啓, 太田敬, 横川文彬,藤井衛之, 五十嵐峻, 土屋弘行
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山
  • Year and Date: 2015-10-22
• [Presentation] 液体窒素処理骨を用いた椎体再建における骨形成過程の組織学的検討 (2015)
  • Author(s): 新村和也
  • Organizer: 日本脊椎脊髄病学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-04-16 – 2015-04-18
• [Presentation] 液体窒素処理骨を用いた椎体再建における骨形成過程の組織学的検討 (2015)
  • Author(s): 新村和也, 村上英樹, 出村諭, 加藤仁志, 吉岡克人, 林寛之, 井上啓, 太田敬, 横川文彬,藤井衛之, 五十嵐峻, 土屋弘行
  • Organizer: 第44回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-04-16
• [Presentation] 液体窒素処理骨を用いた椎体再建における骨形成過程の組織学的検討 (2014)
  • Author(s): 新村和也
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-09 – 2014-10-10