Establishment of novel cartilage regeneration therapy for growth plate injury in children
| Project/Area Number |
26861188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 成長軟骨帯損傷 / 骨製架橋 / 肋軟骨 / 変形矯正 / 成長軟骨 / 損傷 / 再生 |
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| Outline of Final Research Achievements |
Growth plate injury in children bring about the deformity and shortening of limb and development of regeneration therapy for growth plate injury has been expected. In this study, the transplantation of rabbit costal cartilage for growth plate injury was performed. A partial growth plate injury model in rabbits was prepared and transplantation was performed. After surgery, image evaluation and histological evaluation was conducted. In the image evaluation, deformities of lower limb were significantly improved in the costal cartilage transplantation compared to the control group. In the histological evaluation, bony bridge at the injured site was decreased in the costal cartilage group and the regeneration of cartilage like cells having a columnar layer structure at the transplantation site was observed and these cells were deeply stained by Safranin O staining. There results showed that the costal cartilage transplantation could be useful for the growth plate injury.
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Report
(4 results)
Research Products
(4 results)
