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Molecular changes of tendon and muscle after Achilles tendon repair in sarcopenia mouse

Research Project

Project/Area Number 26861192
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKobe University

Principal Investigator

Inui Atsuyuki  神戸大学, 医学部附属病院, 医員 (70457092)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords腱損傷 / サルコペニア / 老化 / 脂肪変性 / 腱断裂 / SAMP6
Outline of Final Research Achievements

We analyzed the molecular changes after tendon repair using senescence accelerated mouse (SAM) model.Forty weeks old animal was used. On the hind limb, Achilles tendon was transected then repaired. Two weeks after the surgery,frozen sections with Oil red-O staining and Real-time PCR was performed.
Tendon:Gene expression of collagen 3 and adipogenic markers were lower in SAM-P6 group. In oil red-O staining, oil droplets were observed at the surface of the tendon in both groups. Muscle:The gene expression of Atrogin was higher while Myogenin was lower in SAM-P6 group.Both PPARγ and C/EBP were higher in SAM-P6 group. In oil red-O staining, more oil droplets were observed in muscle of SAM-P6 group. The molecular change of tendon and muscle after tendon repair showed novel insight to geriatric orthopaedics and would be helpful to treat elderly patients with tendon damage.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 老化モデルマウスにおけるアキレス腱修復後の筋腱の脂肪変性の検討2016

    • Author(s)
      乾淳幸 植田安洋 西本華子 美舩泰 酒井良忠
    • Organizer
      第53回日本リハビリテーション医学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular changes of tendon and muscle after Achilles tendon repair in senescence accelerated mouse2016

    • Author(s)
      Atsuyuki Inui ; Yasuhiro Ueda ;Takeshi Kokubu ; Yutaka Mifune, Ryosuke Sakata Yoshifumi Harada ; Fumiaki Takase ; Takeshi Kataoka ; Masahiro Kurosaka
    • Organizer
      Orthopaedic Research Society 62nd Annual Meeting 2016
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2016-03-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2017-05-10  

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