Development of new strategy for rheumatoid arthritis and osteoarthritis applying human mesenchymal stem cells
| Project/Area Number |
26861214
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Showa University |
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Principal Investigator |
Sato Atsushi 昭和大学, 医学部, 講師 (10445596)
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| Research Collaborator |
OHTAKI HIROKAZU
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 変形性膝関節症 / 骨髄間葉系幹細胞 / 関節リウマチ / ヒト変形性膝関節症 / 骨髄間葉系幹細胞（hMSCs） / 抗炎症作用 / 免疫調節作用 / 関節炎 / 免疫調整作用 |
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| Outline of Final Research Achievements |
Cell therapy for rheumatoid arthritis and osteoarthritis is becoming important recently. One of the treatment method is human mesenchymal stem cells (hMSCs). Inflammatory cytokines such as IL-1, TNF alpha, IL-10 and TGF beta, decreased and an anti-inflammatory cytokine IL-4 increased after spinal cord injury in mice transplanted hMSCs. We revealed that hMSCs regulated anti-inflammatory effect through pituitary adenylate cyclase activating peptide (PACAP). We also reported that chemokine CCL5 and its receptor, CCR1 and CCR5, increased through 14th day after injury by RT-PCR using mRNA of injured tissues. It suggested that CCL5 was involved in chronic inflammatory phase and It was important for the treatment period.
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Report
(5 results)
Research Products
(41 results)
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[Journal Article] Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).2015
Author(s)
Tsumuraya T, Ohtaki H, Song D, Sato A, Watanabe J, Hiraizumi Y, Nakamachi T, Xu Z, Dohi K, Hashimoto H, Atsumi T, Shioda S.
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Journal Title
J Neuroinflammation.
Volume: 12(1)
Issue: 1
Pages: 35-35
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The incidence of DVT/PE between one-staged bilateral and unilateral TKA using constrast enhanced CT and venous ultrasonography in Japanese patients2017
Author(s)
Atsushi Sato, Soshi Asai, Fumiyoshi Kawashima, Masahiko Maekawa, Shin Kato, Takayuki Koya, Naoki Okuma, Takayuki Okumo, Jun Oike, Yushi Hoshino, Kazunari Tomita, Hiroshi Takagi
Organizer
Asia-Pacific knee Arthroscopy and Sports Medicine Society (APKASS)
Related Report
Int'l Joint Research
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