Mutual effects between volatile anesthetics and sympathetic stimulation on cardiac IKs channels

• Project/Area Number: 26861219
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Mikuni Ikuomi 旭川医科大学, 医学部, 助教 (10623895)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: IKsに対するセボフルランの抑制作用 / IKsに対するイソプロテレノールの増幅作用 / IKsに対するセボフルランの抑制効果 / IKsに対するイソプロテレノールの増幅効果 / 実験記録環境の確立

Outline of Final Research Achievements

We confirmed the inhibitory effects of sevoflurane on IKs channels expressed in HEK-293 cells. Additionally, we also confirmed the increasing effects of isoproterenol on IKs channels.