Very short exposure of volatile anesthetics induces long-term learning deficit in adult rats
| Project/Area Number |
26861239
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
UCHIMOTO Kazuhiro 横浜市立大学, 医学(系)研究科(研究院), 客員講師 (50710951)
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| Research Collaborator |
MIYAZAKI Tomoyuki
MIHARA Takahiro
TOMINAGA Yosuke
ASAKURA Ayako
YUBA Yuki
YONEZAKI Kumiko
ADACHI Akiko
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 全身麻酔 / 吸入麻酔薬 / 海馬 / 長期増強 / AMPA受容体 / 神経可塑性 / 認知記憶障害 / 記憶学習 / 受動回避 / グルタミン酸受容体 |
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| Outline of Final Research Achievements |
Volatile anesthetics induces long-term deficits of cognition and learning.The IA test showed that hippocampal learning were suppressed at 7 days after very short exposure - 5 minutes. We revealed that hippocampal LTP and trafficking of GluA1 containing AMPAR were suppressed. Very short exposure model of Sevoflurane induces a long-term deficit of cognition and learning.
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Report
(3 results)
Research Products
(2 results)
