Very short exposure of volatile anesthetics induces long-term learning deficit in adult rats

Research Project

Project/Area Number	26861239
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Yokohama City University
Principal Investigator	UCHIMOTO Kazuhiro 横浜市立大学, 医学(系)研究科(研究院), 客員講師 (50710951)
Research Collaborator	MIYAZAKI Tomoyuki MIHARA Takahiro TOMINAGA Yosuke ASAKURA Ayako YUBA Yuki YONEZAKI Kumiko ADACHI Akiko
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	全身麻酔 / 吸入麻酔薬 / 海馬 / 長期増強 / AMPA受容体 / 神経可塑性 / 認知記憶障害 / 記憶学習 / 受動回避 / グルタミン酸受容体
Outline of Final Research Achievements	Volatile anesthetics induces long-term deficits of cognition and learning.The IA test showed that hippocampal learning were suppressed at 7 days after very short exposure - 5 minutes. We revealed that hippocampal LTP and trafficking of GluA1 containing AMPAR were suppressed. Very short exposure model of Sevoflurane induces a long-term deficit of cognition and learning.

Report

(3 results)