Search of a novel biomarker of over active bladder using metabolomics analysis

• Project/Area Number: 26861263
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: University of Yamanashi
• Principal Investigator: MIYAMOTO Tatsuya 山梨大学, 総合研究部, 助教 (80456459)
• Research Collaborator: TAKEDA Masayuki 山梨大学, 総合研究部, 教授 (80197318) ; KIRA Satoru 山梨大学, 総合研究部, 助教 (10530115)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 過活動膀胱 / メタボロミクス

Outline of Final Research Achievements

Control group (n=26): Urgency score of International Prostate Symptom Score (IPSS) is 0 or 1 and nocturial score is 0 or 1 Over active bladder (OAB) group (n=32): Urgency score of IPSS is 2 ≦ and nocturial score is 2 ≦
We collected the blood samples of all patients and analyzed them using metabolomics. Tetradecanoic acd and Erucic acid are higher level in OAB Group than in control group. These metabolites may be involved with onset of OAB and become a novel biomarker of OAB.