The role of 5-HT3 receptor in bladder sensation

Research Project

Project/Area Number	26861267
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Osaka University
Principal Investigator	Takezawa Kentaro 大阪大学, 医学部附属病院, 医員 (90648015)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	過活動膀胱 / 5-HT3受容体 / 膀胱炎 / 膀胱
Outline of Final Research Achievements	This study investigated the role of serotonin type 3 receptor (5-HT3 receptor) in bladder sensation. I found that 5-HT3 receptor is abundantly expressed on primary bladder afferent nerves, activation of 5-HT3 receptor causes bladder hyperactivity, and blockade of 5-HT3 receptor inhibits the cystitis-induced bladder hyperactivity in mice. These findings indicate the novel mechanisms of bladder hyperactivity mediated by 5-HT3 receptor, and suggest that 5-HT3 receptor may be a potential therapeutic target for overactive bladder syndrome.