The role of 5-HT3 receptor in bladder sensation
| Project/Area Number |
26861267
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 過活動膀胱 / 5-HT3受容体 / 膀胱炎 / 膀胱 |
|---|
| Outline of Final Research Achievements |
This study investigated the role of serotonin type 3 receptor (5-HT3 receptor) in bladder sensation. I found that 5-HT3 receptor is abundantly expressed on primary bladder afferent nerves, activation of 5-HT3 receptor causes bladder hyperactivity, and blockade of 5-HT3 receptor inhibits the cystitis-induced bladder hyperactivity in mice. These findings indicate the novel mechanisms of bladder hyperactivity mediated by 5-HT3 receptor, and suggest that 5-HT3 receptor may be a potential therapeutic target for overactive bladder syndrome.
|
Report
(3 results)
Research Products
(1 results)
