Investigation of hypoxia resistance in renal cell carcinoma based on functional RNA network analyses
Project/Area Number |
26861276
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Kagoshima University |
Principal Investigator |
Chiyomaru Takeshi 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (60593796)
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Research Collaborator |
NAKAGAWA MASAYUKI 鹿児島大学, 医歯学総合研究科, 教授 (90164144)
ENOKIDA HIDEKI 鹿児島大学, 医歯学総合研究科, 准教授 (80347103)
SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 腎細胞癌 / マイクロRNA / 低酸素 / microRNA |
Outline of Final Research Achievements |
We found that MYC oncogene was directory regulated by miR-135a. miR-1291 also regulated glucose transporter 1 (SLC2A1/GLUT1). miR-143/145 is a tumor suppressive cluster microRNA, and they had a common target hexokinase 2 gene. Down regulation of miR-135a, miR-1291, miR-143, and miR-145 might activate glycolytic pathway and maintain ATP synthesis under hypoxia circumstances in renal cell carcinoma.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Expression of the tumor suppressive miRNA-23b/27b cluster is a good prognostic marker in clear cell renal cell carcinoma.2014
Author(s)
Ishihara T, Seki N, Inoguchi S, Yoshino H, Tatarano S, Yamada Y, Itesako T, Goto Y, Nishikawa R, Nakagawa M, Enokida H.
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Journal Title
The Journal of Urology
Volume: 192
Issue: 6
Pages: 1822-1830
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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