| Project/Area Number |
26861276
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Chiyomaru Takeshi 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (60593796)
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| Research Collaborator |
NAKAGAWA MASAYUKI 鹿児島大学, 医歯学総合研究科, 教授 (90164144)
ENOKIDA HIDEKI 鹿児島大学, 医歯学総合研究科, 准教授 (80347103)
SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 腎細胞癌 / マイクロRNA / 低酸素 / microRNA |
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| Outline of Final Research Achievements |
We found that MYC oncogene was directory regulated by miR-135a. miR-1291 also regulated glucose transporter 1 (SLC2A1/GLUT1). miR-143/145 is a tumor suppressive cluster microRNA, and they had a common target hexokinase 2 gene. Down regulation of miR-135a, miR-1291, miR-143, and miR-145 might activate glycolytic pathway and maintain ATP synthesis under hypoxia circumstances in renal cell carcinoma.
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