Investigation of novel diagnostic biomarkers for prostate cancer based on RM2 antigen

Research Project

Project/Area Number	26861277
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	University of the Ryukyus
Principal Investigator	SUDA Tetsuji 琉球大学, 医学(系)研究科(研究院), 助教 (40423347)
Co-Investigator(Renkei-kenkyūsha)	SAITO Seiichi 琉球大学, 医学研究科, 教授 (80235043) NAKANISHI Shotaro 琉球大学, 医学研究科, 助教 (40725321)
Research Collaborator	KANEYUKI Ayako SUGAWA Ai
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	前立腺癌 / 糖鎖 / 糖蛋白 / マーカー
Outline of Final Research Achievements	Although RM2 antigen is a new histological marker for prostate cancer that may reflect the tumor stage, the target proteins carrying RM2 antigen are yet unclear. To identify the target proteins, we focused on amino acid sequence of the 50kDa protein that reacts strongly to RM2 antibody. Histological expression of several candidate proteins in prostate cancer was significantly associated with Gleason score. Among these, urine level of a candidate protein in the patients with prostate cancer decreased compared to those with benign prostate. These results suggested that these candidate proteins would be useful as a new histological or urine marker of prostate cancer.