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The role of GDNF-RET cascade for the development of benign prostate hyperplasia

Research Project

Project/Area Number 26861285
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

SHIBATA Yasuhiro  名古屋市立大学, 大学院医学研究科, 助教 (10534745)

Research Collaborator SASAKI Shoichi  名古屋市立大学, 大学院医学研究科, 研究員 (50225869)
UGAWA Shinya  名古屋市立大学, 大学院医学研究科, 教授 (20326135)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords前立腺肥大症 / GDNF / 前立腺 / GZF1 / 前立腺肥大症モデルラット
Outline of Final Research Achievements

Although benign prostate hyperplasia (BPH) is common disease, the cause of BPH is still unclear. To investigate the mechanism of BPH development, we use the novel BPH model which was made by implanting the urogenital sinus of neonatal rats to sub-capsule of the prostate of adult male rats.  Using this model we discovered the grail-cell derived neurotrophic factor (GDNF) expresses in interstitial cell. And we demonstrate that GDNF increase the growth rate of human prostate interstitial cell-line, and RET signal cascade was related with prostate volume positively in human BPH tissue.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results)

  • [Journal Article] Distribution of ASIC4 transcripts in the adult wild-type mouse brain.2017

    • Author(s)
      Hoshikawa M, Kato A, Hojo H, Shibata Y, Kumamoto N, Watanabe M, Ugawa S.
    • Journal Title

      Neurosci Lett.

      Volume: 印刷中 Pages: 57-64

    • DOI

      10.1016/j.neulet.2017.03.054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and regulation of Cav3.2 T-type calcium channels during inflammatory hyperalgesia in mouse dorsal root ganglion neurons.2015

    • Author(s)
      Watanabe M, Ueda T (co-author and corresponding author), Shibata Y, Kumamoto N, Shimada S, Ugawa S.
    • Journal Title

      PLoS One

      Volume: 10(5) Issue: 5 Pages: 1-19

    • DOI

      10.1371/journal.pone.0127572

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of TRPV1 channels in carrageenan-induced mechanical hyperalgesia in mice.2015

    • Author(s)
      Watanabe M, Ueda T, Shibata Y, Kumamoto N, Ugawa S.
    • Journal Title

      Neuroreport

      Volume: 26 Issue: 3 Pages: 173-178

    • DOI

      10.1097/wnr.0000000000000322

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells.2014

    • Author(s)
      Hamakawa Takashi, Sasaki Shoichi, Shibata Yasuhiro, Imura Makoto, Kubota Yasue, Kojima Yoshiyuki, Kohri Kenjiro
    • Journal Title

      Prostate

      Volume: 74 Issue: 6 Pages: 590-601

    • DOI

      10.1002/pros.22773

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 免疫電顕法を用いたマウス前提におけるASIC1bの発現と分布2017

    • Author(s)
      柴田泰宏 星川真理子 熊本奈都子 植田高史 鵜川眞也
    • Organizer
      第122会日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウス前庭系におけるASIC1bの発現と分布2016

    • Author(s)
      柴田泰宏 星川真理子 熊本奈都子 植田高史 鵜川眞也
    • Organizer
      第17回ORIGIN神経科学研究会
    • Place of Presentation
      あわら温泉まつや千千(福井県あわら市)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウス前庭系有毛細胞におけるASIC1bの発現と分布2016

    • Author(s)
      柴田泰宏 星川真理子 熊本奈都子 植田高史 鵜川眞也
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま 福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス脳におけるASIC4の分布と機能解析2015

    • Author(s)
      柴田泰宏 星川真理子 熊本奈都子 植田高史 鵜川眞也
    • Organizer
      日本解剖学会第75回中部支部学術集会
    • Place of Presentation
      福井大学松岡キャンパス 白翁会ホール 福井県吉田郡
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] mASIC4 is a Zn-sensitive constitutively active channel2015

    • Author(s)
      Yasuhiro Shibata, Masaya Watanabe, Mariko Hoshikawa, Natsuko Kumamoto, Takashi Ueda, Shinya Ugawa
    • Organizer
      第120回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Distribution of ASIC4 channel in the mouse brain2015

    • Author(s)
      Mariko Hoshikawa, Yasuhiro Shibata, Natsuko Kumamoto, Takashi Ueda,Shinya Ugawa
    • Organizer
      第120回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Gene expression analysis of ASIC subtypes in adult-born hippocampal neurons in mice2015

    • Author(s)
      Natsuko Kumamoto, Mariko Hoshikawa, Masaya Watanabe, Yasuhiro Shibata, Takashi Ueda, Shinya Ugawa
    • Organizer
      第120回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional expression of TRPV4 receptor in mouse nasal epithelium2015

    • Author(s)
      Takashi Ueda, Natsuko Kumamoto, Mariko Hoshikawa, Masaya Watanabe, Yasuhiro Shibata, Shinya Ugawa
    • Organizer
      第120回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] mASIC4 is a Zn-sensitive constitutively active channel2014

    • Author(s)
      Yasuhiro Shibata, Masaya Watanabe, Mariko Hoshikawa, Natsuko Kumamoto, Takashi Ueda, Shinya Ugawa
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良県文化会館・奈良県新公会堂(奈良県奈良市)
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスASIC4は亜鉛感受性の常時活性型チャネルである2014

    • Author(s)
      柴田 泰宏 星川真理子 渡辺 正哉 熊本 奈都子 植田 高史 鵜川 眞也
    • Organizer
      第15回 ORIGIN 神経科学研究会 夏のワークショップ
    • Place of Presentation
      浅間温泉地本屋(長野県松本市)
    • Year and Date
      2014-08-31 – 2014-09-01
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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