| Project/Area Number |
26861290
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nara Medical University |
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Principal Investigator |
Miyake Makito 奈良県立医科大学, 医学部, 助教 (80601400)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Bladder cancer / tumor micro environment / macrophage / fibroblast / bladder cancer / tumor microenvironment / 癌進展機構 / マクロファージ / 線維芽細胞 |
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| Outline of Final Research Achievements |
Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are reported to have association with poor prognosis, depending on their tumor-supportive roles. Current knowledge of TAMs and CAFs in tumor microenvironment of urothelial cancer the bladder (UCB) is limited. Here, we focused on the biological behavior of CXCL1 signaling for induction of TAMs/CAFs which support the tumor growth and angiogenesis. In conclusion, CXCL1 signaling in tumor microenvironment may be highly responsible for repeated intravecial recurrence and disease progression through enhanced invasion ability. Breaking the CXCL1 signaling is an attractive therapeutic approach for human UCB in which this chemokine is aberrantly regulated.
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