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Investigation of the expression of vasohibin regulated by the epigenetic mechanism in urothelial carcinoma

Research Project

Project/Area Number 26861300
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKeio University

Principal Investigator

Miyazaki Yasumasa  慶應義塾大学, 医学部, 共同研究員 (80445329)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords尿路上皮癌 / 血管新生 / エピジェネティクス / 血管内皮細胞 / 血管新生阻害剤 / 上皮間葉転換 / メチル化 / バイオマーカー
Outline of Final Research Achievements

We investigated the expression of vasohibin-1(VASH1) and vasohibin-2(VASH2) in urothelial carcinoma. VASH1 was especially expressed in the endothelial cells of the tumor stroma. Enhancer of zeste (EZH) 2, a methyltransferase and component of the polycomb repressive complex 2 (PRC2), plays an essential role in the epigenetic maintenance of the Histone H3 trimethyl Lys27 (H3K27me3) repressive chromatin mark. Because EZH2 associated the expression of vasohibin in the previous reports, we evaluated the immunohistochemical staining of EZH2, H3K27me3, and VASH1 in patients with urothelial carcinoma. EZH2 and H3K27me3 associated the grade of tumor, pathological T stage, and vasohibin-1 expression. These results suggested that the VASH1 associated with H3K27me3 and could be regulated by the epigenetic mechanism.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015

All Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] The prognostic impact of Histone H3K27 trimethylation by EZH2 in patients with upper urinary tract urothelial carcinoma2015

    • Author(s)
      宮崎保匡
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場, 名古屋市熱田区熱田西町1番1号
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] The prognostic impact of Histone H3K27 trimethylation regulated by EZH2 in patients with upper urinary tract urothelial carcinoma2015

    • Author(s)
      宮崎保匡
    • Organizer
      2015年度 米国泌尿器科学会総会 (AUA 2015)
    • Place of Presentation
      Ernest N. Morial Convention Center, 900 Convention Center Blvd, New Orleans, LA 70130, USA
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 尿路上皮癌における血管新生調節因子バソヒビンとエピジェネティクス制御機構の解明2015

    • Author(s)
      宮崎保匡
    • Organizer
      第103回 日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂コンサートホール, 石川県金沢市昭和町20-1
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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