Establishment of new therapeutics for ovarian cancer metastasis: ceramide-based therapy
| Project/Area Number |
26861304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
KITATANI Kazuyuki 東北大学, 東北メディカル・メガバンク機構, 助教 (40539235)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | セラミド / 卵巣がん / 転移 / 細胞運動性 / セラミドリポソーム |
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| Outline of Final Research Achievements |
Ovarian cancer is one of major Gynecologic cancer and improving cancer metastasis and recurrence is socially urgent. Cell motility is believed to promote metastasis. Uncovering the molecular mechanisms in cell motility regulation is expected to develop novel therapeutics. The Pi has identified ceramide as a novel suppressor in cell motility that promotes cancer metastasis. Those results allowed us to examine effects of ceramdei formulations on ovarian cancer metastasis. Ovarian cancer metastasis model has been established by xenografting human varian cancer SKOV3 cells in nude mice. Treatment of nude mice with ceramide formulation significantly suppressed the metastasis. Our studies could promoted to develop ceramide-based therapy for ovarian cancer treatment.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid2015
Author(s)
Kitatani K, Usui T, Sriraman S, Toyoshima M, Ishibashi M, Shigeta S, Nagase S, Sakamoto M, Hannun Y, Torchilin V, Okazaki T, Ogiso H, Yaegashi N
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Journal Title
Oncogene
Volume: -
Issue: 21
Pages: 2801-2812
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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