Establishment of new therapeutics for ovarian cancer metastasis: ceramide-based therapy

• Project/Area Number: 26861304
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: KITATANI Kazuyuki 東北大学, 東北メディカル・メガバンク機構, 助教 (40539235)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: セラミド / 卵巣がん / 転移 / 細胞運動性 / セラミドリポソーム

Outline of Final Research Achievements

Ovarian cancer is one of major Gynecologic cancer and improving cancer metastasis and recurrence is socially urgent. Cell motility is believed to promote metastasis. Uncovering the molecular mechanisms in cell motility regulation is expected to develop novel therapeutics. The Pi has identified ceramide as a novel suppressor in cell motility that promotes cancer metastasis. Those results allowed us to examine effects of ceramdei formulations on ovarian cancer metastasis. Ovarian cancer metastasis model has been established by xenografting human varian cancer SKOV3 cells in nude mice. Treatment of nude mice with ceramide formulation significantly suppressed the metastasis. Our studies could promoted to develop ceramide-based therapy for ovarian cancer treatment.

Research Products

• [Int'l Joint Research] Stony Brook University/Northeastern University(米国)
• [Journal Article] Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid (2015)
  • Author(s): Kitatani K, Usui T, Sriraman S, Toyoshima M, Ishibashi M, Shigeta S, Nagase S, Sakamoto M, Hannun Y, Torchilin V, Okazaki T, Ogiso H, Yaegashi N
  • Journal Title: Oncogene Volume: - Issue: 21 Pages: 2801-2812
  • DOI: 10.1038/onc.2015.330
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Possible involvement of ceramide synthase in regulatory mechanism of ovarian cancer metastasis. (2016)
  • Author(s): Kazuyuki Kitatani, Zhang Xuewei, Masafumi Toyoshima, Masumi Ishibashi, Shogo Shigeta, Nobuo Yaegashi
  • Organizer: 63th Society for Reproductive Investigation
  • Place of Presentation: Palais des congres de Montreal，モントリオール，カナダ
  • Year and Date: 2016-03-16
  • Int'l Joint Research
• [Presentation] 卵巣がん転移に関わるセラミド生成代謝酵素 (2016)
  • Author(s): 北谷和之，張雪薇，臼井利典，豊島将文，重田昌吾，石橋ますみ，湊純子，小木曽英夫， 岡崎俊朗，八重樫伸生
  • Organizer: 第４回婦人科がんバイオマーカー研究会
  • Place of Presentation: 岐阜大学サテライト，岐阜県岐阜市
  • Year and Date: 2016-02-27
• [Presentation] Ceramide Limits Phosphatidylinositol-3-Kinase C2β-Controlled Cell Motility in Ovarian Cancer: Potential of Ceramide liposomes as Antimetastatic Agents (2015)
  • Author(s): Kazuyuki Kitatani
  • Organizer: SRI 62nd Annual Scientific Meeting
  • Place of Presentation: サンフランシスコ（米国）
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] セラミドによる卵巣がん播種転移制御 (2015)
  • Author(s): 北谷和之
  • Organizer: 第３回婦人科がんバイオマーカー研究会
  • Place of Presentation: 九州大学医学部百年講堂（福岡市、福岡県）
  • Year and Date: 2015-02-21
• [Remarks] 東北大学 大学院医学系産科婦人科
  • URL: http://www.ob-gy.med.tohoku.ac.jp/staff/event-index.html
• [Remarks] 東北大学 東北メディカル・メガバンク機構
  • URL: http://www.megabank.tohoku.ac.jp/tommo/member/member02