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Study on endolymphatic hydrostatic pressure regulating function of endolymphatic sac

Research Project

Project/Area Number 26861387
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKagawa University

Principal Investigator

Inamoto Ryuhei  香川大学, 医学部附属病院, 助教 (50581047)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Keywords内リンパ嚢 / 蝸牛 / 前庭 / カテコールアミン / 内リンパ静水圧 / 外リンパ静水圧 / 前庭・半規管 / 内リンパ / 外リンパ / 静水圧 / イソプロテレノール / 蝸牛内リンパ圧 / 蝸牛外リンパ圧 / 前庭内リンパ圧 / 前庭外リンパ圧
Outline of Final Research Achievements

The hydrostatic pressures of endolymph and perilymph in the ampulla and cochlea were similar in magnitude. Isoproterenol significantly increased hydrostatic pressure of ampullar and cochlear endolymph and perilymph with no change in the ampullar endolymphatic potential and endocochlear potential, respectively. The isoproterenol-induced maximum change of endolymphatic hydrostatic pressure in ampulla was significantly (p < 0.01) smaller than that in the cochlea. In ears with an obstructed endolymphatic sac, the action of isoproterenol on endolymphatic hydrostatic pressure in the ampulla disappeared like that in the cochlea. Isoproterenol elevates endolymphatic hydrostatic pressure in different manner between the vestibule and the cochlea.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] The difference in endolymphatic hydrostatic pressure elevation induced by isoproterenol between the ampulla and the cochlea.2017

    • Author(s)
      Inamoto R, Miyashita T, Matsubara A, Hoshikawa H, Mori N.
    • Journal Title

      Auris Nasus Larynx

      Volume: Jun;44(3) Issue: 3 Pages: 282-287

    • DOI

      10.1016/j.anl.2016.07.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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