The Research on Nox producing Reactive Oxygen Species in Head and Neck carcinoma
Project/Area Number |
26861391
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Kyushu University |
Principal Investigator |
Masahiko Taura 九州大学, 医学研究院, 共同研究員 (20648026)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 頭頸部癌 / 甲状腺癌 / 食細胞 / 活性酸素 / Nox / Duox / 貪食 / sTNF-R / 唾液腺癌 / 腫瘍マーカー / 頭頸部扁平上皮癌 / 活性酸素生成酵素NOX / 慢性中耳炎 / 白血球貪食能 / 白血球殺菌能 / 難聴 / NADPHオキシダーゼ / 頭頸部悪性腫瘍 / 扁平上皮癌 |
Outline of Final Research Achievements |
We Researched on Nox(NADPH oxidase) producing ROS(Reactive Oxygen Species) in Head and Neck carcinoma and Duox producing ROS in Thyroid carcinoma. A hypothesis was built up that Nox expression in Head and Neck carcinoma patients was reduced and could not produce enough ROS to kill the carcinoma cells. In head and neck patients, Nox2 was expressed but the other Nox was not. Nox2 expression in advanced carcinoma was as same amout as in initial cancer. In thyroid cancer patients, Duox2 expression was decreased in advanced cancer. Duox producing ROS may effect the rate of progression in thyroid cancer. Another hypothesis was built up that cytokines connecting with Nox, phagocytosis, apoptosis, and ROS were lower than healthy people. None of the cytokines were reduced in carcinoma patients. sTNF-R type1 and type2 were increased significantly in the Head and neck carcinoma patients. We can use sTNF-R as the novel tumor marker for head and heck cancer.
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Report
(4 results)
Research Products
(4 results)