• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular analysis of epithelial and fibroblastic celsl in IgG4-related disease

Research Project

Project/Area Number 26861401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionSapporo Medical University

Principal Investigator

Abe Ayumi  札幌医科大学, 医学部, 研究員 (80644468)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsIgG4関連疾患 / 唾液腺 / 上皮バリア / タイト結合 / 細胞・組織 / 導管上皮細胞
Outline of Final Research Achievements

We examined submandibular gland (SMG) tissue from control individuals and patients with IgG4-RD and established an HSDEC culture system. Claudin-4, claudin-7, occludin, and JAMA were expressed at the apical side of the duct epithelium in SMG tissue and at the cell borders in HSDECs of normal and IgG4-RD. The expression and distribution of TJs in SMG tissue were not different in control individuals and patients with IgG4-RD in vivo and in vitro. Although interferon-gamma (IFNg) generally disrupts the integrity and function of TJs, IFNg markedly increased the epithelial barrier function of HSDECs via upregulation of claudin-7 expression in HSDECs from patients with IgG4-RD. This is the first report showing an IFNg-dependent increase in epithelial barrier function in the salivary gland duct epithelium. Our results provide insights into the functional significance of TJs in salivary gland duct epithelium in physiological and pathological conditions, including IgG4-RD.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (4 results)

  • [Journal Article] Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.2016

    • Author(s)
      Abe A, Takano K, Kojima T, Nomura K, Kakuki T, Kaneko Y, Yamamoto M, Takahashi H, Himi T
    • Journal Title

      J Mol Histol

      Volume: 未定 Issue: 3 Pages: 353-363

    • DOI

      10.1007/s10735-016-9667-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinicopathological analysis of salivary gland tissue from patients with IgG4-related disease.2016

    • Author(s)
      Takano K, Nomura K, Abe A, Kamekura R, Yamamoto M, Ichimiya S, Takahashi H, Himi T
    • Journal Title

      Acta Otolaryngol

      Volume: 未定 Issue: 7 Pages: 1-5

    • DOI

      10.3109/00016489.2016.1154605

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A case of progressively transformed germinal center-type IgG4-related lymphadenopathy.2016

    • Author(s)
      Seki N, Yamazaki N, Koizumi J, Takano K, Abe A, Ikeda T, Noguchi H, Himi T
    • Journal Title

      Auris Nasus Larynx

      Volume: 42 Issue: 4 Pages: 345-347

    • DOI

      10.1016/j.anl.2015.02.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease.2015

    • Author(s)
      Takano K, Abe A, Yajima R, Kakuki T, Jitsukawa S, Nomura K, Himi T
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 124 Issue: 12 Pages: 965-971

    • DOI

      10.1177/0003489415593557

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The clinical characteristics of patients with IgG4-related disease with infiltration of the labial salivary gland by IgG4-positive cells2014

    • Author(s)
      Abe A, Takano K, Seki N, Himi T. (7名7番)
    • Journal Title

      Mod Rheumatol

      Volume: 26 Issue: 6 Pages: 949-952

    • DOI

      10.3109/14397595.2014.891964

    • URL

      http://informahealthcare.com/doi/abs/

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] IgG4関連疾患における顎下腺導管上皮タイト結合分子の発現変化2015

    • Author(s)
      阿部亜由美,高野賢一,亀倉隆太,氷見徹夫
    • Organizer
      第24回日本シェーグレン症候群学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区_
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] IgG4関連疾患における顎下腺導管上皮タイト結合分子の発現変化2015

    • Author(s)
      阿部亜由美,高野賢一,亀倉隆太,氷見徹夫
    • Organizer
      第28回日本口腔・咽頭科学会
    • Place of Presentation
      ホテル大阪(大阪市福島区)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当科で経験した先天性副耳下腺頬部皮膚瘻の1例2015

    • Author(s)
      阿部亜由美
    • Organizer
      第25回日本頭頸部外科学会総会ならびに学術講演会
    • Place of Presentation
      コングレコンベンションセンター(大阪府大阪市)
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 耳下腺原発オンコサイト癌の1例2014

    • Author(s)
      阿部亜由美
    • Organizer
      第 27 回日本口腔・咽頭科学会
    • Place of Presentation
      ホテルライフォート札幌(北海道札幌市)
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi