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The morphological change of auditory association area in deaf model rat

Research Project

Project/Area Number 26861407
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionYokohama City University

Principal Investigator

ARAI Yasuhiro  横浜市立大学, 附属病院, 助教 (90614818)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords聾モデルラット / 内側膝状体 / 聴覚中枢路 / 聴覚連合野 / 人工内耳
Outline of Final Research Achievements

The purpose of this study is to elucidate auditory nerve and myelination to auditory association area which is important for language understanding in order to understand neuroanatomically the development and understanding of speech in the persons with deaf -mutism. We used normal rats and deaf model rats in this study. We injected neuronal tract-trace into the auditory association area in normal and deaf model rats. After 1 week, we observed medial geniculate body of brain in each normal and deaf model rats. There were not significant different cellular number and size between normal and deaf model rat. Then, we immunostained with anti MBP antibody and anti GFAP antibody in order to clarify the myelination and the relation with macroglia in the auditory centers. There were not significant difference between normal and deaf model rat.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] An effective screening strategy for deafness in combination with a next-generation sequencing platform: a consecutive analysis.2016

    • Author(s)
      Sakuma N, Moteki H, Takahashi M, Nishio SY, Arai Y, Yamashita Y, Oridate N, Usami S.
    • Journal Title

      J Hum Genet.

      Volume: 61 Issue: 3 Pages: 253-261

    • DOI

      10.1038/jhg.2015.143

    • NAID

      40020766326

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel PTPRQ mutations identified in three congenital hearing loss patients with various types of hearing loss.2015

    • Author(s)
      Sakuma N, Moteki H, Azaiez H, Booth KT, Takahashi M, Arai Y, Shearer AE, Sloan CM, Nishio SY, Kolbe DL, Iwasaki S, Oridate N, Smith RJ, Usami S.
    • Journal Title

      Ann Otol Rhinol Laryngol.

      Volume: 124 Issue: 1_suppl Pages: 184S-192S

    • DOI

      10.1177/0003489415575041

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel PTPRQ mutations identified in three congenital hearing loss patients with various types of hearing loss.2015

    • Author(s)
      Sakuma N, Moteki H, Araiez H, Booth KT, Takahashi M, Arai Y, Shearer AE, Sloan CM, Nishio SY, Kolbe DL, Iwasaki S, Oridate N, Smith RJ, Usami SI
    • Journal Title

      Annals of Otology, Rhinology & Laryngology

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2014-04-04   Modified: 2017-05-10  

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