| Project/Area Number |
26861415
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
Kurano Kaori 順天堂大学, 医学部, 助教 (00514522)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 好酸球性副鼻腔炎 / 黄色ブドウ球菌 / スーパー抗原 / 抗菌ペプチド / β-デフェンシン / カテリシジン / カテリシジ |
|---|
| Outline of Final Research Achievements |
Using the nasal polyps derived from eosinophilic chromic rhinosinusitis, the expression of beta-defensin and cathesidin were demonstrated using immuniohistochemistry and chemical assay. Furthermore, antibactertial pepsides secreted from nasal epithelial cells inhibited the adhesion of Staphilococcus auresus on the epithelial cells. Based on the following studies including expression of beta-defensin and cathesidin, responses of antibacterial peptides on eosinoplil-related cytokines, and the adhesion of Staphylococcus auresus, antibacterial peptides may play an important role on defensive factors in the pathogenesis of eosinophilic chromic rhinosinusitis.
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