New strategy based on anti-oxidant action in eosinophilic chronic rhinosinusitis with nasal polyps

Research Project

Project/Area Number	26861417
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Juntendo University
Principal Investigator	Ono Noritsugu 順天堂大学, 医学部, 助教 (10433773)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	好酸球副鼻腔炎 / 鼻茸 / 抗活性酸素因子 / Superoxide dismutase / 好酸球 / マクロファージ / リモデリング / 好酸球性副鼻腔炎
Outline of Final Research Achievements	Twenty-six patients with CRS with nasal polyps were divided into eosinophilic and non-eosinophilic groups. The expression of three isoforms of SOD, intracellular copper-zinc SOD (CuZnSOD), mitochondrial manganese SOD (MnSOD) and extracellular SOD (ECSOD), were examined by enzyme activity assay, immunohistochemistry, and quantitative real-time RT-PCR sampled by laser capture microdissection.