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New strategy based on anti-oxidant action in eosinophilic chronic rhinosinusitis with nasal polyps

Research Project

Project/Area Number 26861417
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionJuntendo University

Principal Investigator

Ono Noritsugu  順天堂大学, 医学部, 助教 (10433773)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords好酸球副鼻腔炎 / 鼻茸 / 抗活性酸素因子 / Superoxide dismutase / 好酸球 / マクロファージ / リモデリング / 好酸球性副鼻腔炎
Outline of Final Research Achievements

Twenty-six patients with CRS with nasal polyps were divided into eosinophilic and non-eosinophilic groups. The expression of three isoforms of SOD, intracellular copper-zinc SOD (CuZnSOD), mitochondrial manganese SOD (MnSOD) and extracellular SOD (ECSOD), were examined by enzyme activity assay, immunohistochemistry, and quantitative real-time RT-PCR sampled by laser capture microdissection.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Correlations between Cu,Zn-SOD and macrophages or MUC5AC in human eosinophilic chronic rhinosinusitis.2015

    • Author(s)
      Kusunoki T, Ono N, Ikeda K.
    • Journal Title

      J Otol Rhinol

      Volume: S1 Pages: 10-14

    • DOI

      10.4172/2324-8785.s1-003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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