| Project/Area Number |
26861417
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 好酸球副鼻腔炎 / 鼻茸 / 抗活性酸素因子 / Superoxide dismutase / 好酸球 / マクロファージ / リモデリング / 好酸球性副鼻腔炎 |
|---|
| Outline of Final Research Achievements |
Twenty-six patients with CRS with nasal polyps were divided into eosinophilic and non-eosinophilic groups. The expression of three isoforms of SOD, intracellular copper-zinc SOD (CuZnSOD), mitochondrial manganese SOD (MnSOD) and extracellular SOD (ECSOD), were examined by enzyme activity assay, immunohistochemistry, and quantitative real-time RT-PCR sampled by laser capture microdissection.
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